{"id":"b32105ff-0bec-599d-9ff3-45add4dd3641","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-carrier-species-expression","predicate":"differs_between_species","statement":"Absolute proteomics found citrin/aralar molar ratios of about 7.8 in mouse liver and 397 in human liver, indicating much less endogenous aralar relative to citrin in humans.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b4d6e568-e86e-50d0-a47a-f712dd16fc3f","mechanism_event_label":"A mouse may compensate for a missing carrier more readily than a human.","subject":{"id":"d2055e30-5c75-5871-83f9-9859d8d15c65","slug":"liver-agc-species-expression","display_name":"Species-dependent liver aspartate-carrier expression","entity_type_key":"cellular_process"},"object":{"id":"73632001-aec1-522c-80dd-7c5d1eda4ebe","slug":"slc25a12","display_name":"Human aralar / SLC25A12","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"b4d6e568-e86e-50d0-a47a-f712dd16fc3f","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-carrier-species-expression-event","event_type":"observed_relationship","label":"A mouse may compensate for a missing carrier more readily than a human.","description":"Absolute proteomics found citrin/aralar molar ratios of about 7.8 in mouse liver and 397 in human liver, indicating much less endogenous aralar relative to citrin in humans.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d2055e30-5c75-5871-83f9-9859d8d15c65","slug":"liver-agc-species-expression","display_name":"Species-dependent liver aspartate-carrier expression","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"73632001-aec1-522c-80dd-7c5d1eda4ebe","slug":"slc25a12","display_name":"Human aralar / SLC25A12","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5252ba8d-8e58-5fa5-abdb-7bc97ef85818","slug":"slc25a13","display_name":"Human citrin / SLC25A13","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"f63c3bfd-d464-53a4-9650-300bb647c282","slug":"mouse-slc25a12","display_name":"Mouse aralar / Slc25a12","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"20ff2646-aa5c-5883-bb28-21f9924c9890","slug":"mouse-slc25a13","display_name":"Mouse citrin / Slc25a13","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse and human liver quantitative proteomics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Sampled expression ratios are not universal constants or proof of a clinical rescue strategy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A mouse may compensate for a missing carrier more readily than a human.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Exogenous aralar/slc25a12 can replace citrin/slc25a13 as malate aspartate shuttle component in liver. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36967723/ · DOI 10.1016/j.ymgmr.2023.100967","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"11438f3a-7223-570e-bc21-c2b64408928b","evidence_kind":"source_excerpt","locator":"Lines 138-144","start_line":138,"end_line":144,"excerpt":"## l-aspartate-carrier-species-expression\nA mouse may compensate for a missing carrier more readily than a human.\nAbsolute proteomics found citrin/aralar molar ratios of about 7.8 in mouse liver and 397 in human liver, indicating much less endogenous aralar relative to citrin in humans.\nModel: Mouse and human liver quantitative proteomics.\nLimitations: Sampled expression ratios are not universal constants or proof of a clinical rescue strategy.\nEvidence access: Primary full text\nExogenous aralar/slc25a12 can replace citrin/slc25a13 as malate aspartate shuttle component in liver. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36967723/ · DOI 10.1016/j.ymgmr.2023.100967","model_system":"Mouse and human liver quantitative proteomics.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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