{"id":"b2dd0039-e089-538e-8559-51f6eaca7f19","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-human-bariatric-expression","predicate":"associated_with_lower_expression","statement":"Human hepatic GPT2 mRNA decreased after bariatric surgery in the study samples.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1dcae90d-fb84-515f-a045-661142173dd0","mechanism_event_label":"A human association complements the mouse mechanism but does not establish the same cause.","subject":{"id":"8de3989e-c433-510e-89ad-0f241ec594ed","slug":"human-bariatric-weight-loss","display_name":"Bariatric surgery-associated weight loss","entity_type_key":"cellular_process"},"object":{"id":"59baef49-fed8-5b6f-90ca-b8efdf021608","slug":"gpt2","display_name":"Human mitochondrial alanine aminotransferase / GPT2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"1dcae90d-fb84-515f-a045-661142173dd0","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-human-bariatric-expression-event","event_type":"observed_relationship","label":"A human association complements the mouse mechanism but does not establish the same cause.","description":"Human hepatic GPT2 mRNA decreased after bariatric surgery in the study samples.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8de3989e-c433-510e-89ad-0f241ec594ed","slug":"human-bariatric-weight-loss","display_name":"Bariatric surgery-associated weight loss","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"59baef49-fed8-5b6f-90ca-b8efdf021608","slug":"gpt2","display_name":"Human mitochondrial alanine aminotransferase / GPT2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ebdc4461-c059-563e-88b0-422c21fdaa25","slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human liver expression measurements before/after surgical weight loss.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Multiple metabolic changes accompany surgery; this is not an alanine intervention. Correction record: Published correction adds the originally omitted disclosure that B.N.F. was a scientific advisory board member and stockholder of Cirius Therapeutics, which develops MPC inhibitors. Disclosure correction, not a data retraction. https://pmc.ncbi.nlm.nih.gov/articles/PMC9713851/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Alanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A human association complements the mouse mechanism but does not establish the same cause.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35476997/ · DOI 10.1016/j.celrep.2022.110733","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9ff030ba-db56-5be6-9b01-349097d3af33","evidence_kind":"source_excerpt","locator":"Lines 240-246","start_line":240,"end_line":246,"excerpt":"## alanine-human-bariatric-expression\nA human association complements the mouse mechanism but does not establish the same cause.\nHuman hepatic GPT2 mRNA decreased after bariatric surgery in the study samples.\nModel: Human liver expression measurements before/after surgical weight loss.\nLimitations: Multiple metabolic changes accompany surgery; this is not an alanine intervention. Correction record: Published correction adds the originally omitted disclosure that B.N.F. was a scientific advisory board member and stockholder of Cirius Therapeutics, which develops MPC inhibitors. Disclosure correction, not a data retraction. https://pmc.ncbi.nlm.nih.gov/articles/PMC9713851/\nEvidence access: Primary full text\nSilencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35476997/ · DOI 10.1016/j.celrep.2022.110733","model_system":"Human liver expression measurements before/after surgical weight loss.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"01c5554c-a8ba-5c86-9b01-a0fa1a886cdb","stable_key":"import-10aa417f-4b03-599f-a453-4aa09edeb27c","title":"L-Alanine: carbon, nitrogen, protein synthesis and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"8ce7dd76c88b2e25fa23d93f9655a244aadb9d90f55ec8b18ecf0fd4625a61d2","revision_id":"4ed32258-0213-599a-a272-6f8f62280773","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}