{"id":"b2a17cbd-03e9-5ab4-a280-1d99032915cf","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-srr-plp","predicate":"binds","statement":"The 1.89-angstrom human serine-racemase holoenzyme structure included its bound pyridoxal-phosphate cofactor.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2fcfa41d-c188-5918-8f8e-abf0e57b469f","mechanism_event_label":"Vitamin B6-derived PLP is part of the shared racemase machinery.","subject":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"object":{"id":"3ea2d19a-b88a-531e-9cd3-a993735143de","slug":"srr","display_name":"Human serine racemase / SRR","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"2fcfa41d-c188-5918-8f8e-abf0e57b469f","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-srr-plp-event","event_type":"observed_relationship","label":"Vitamin B6-derived PLP is part of the shared racemase machinery.","description":"The 1.89-angstrom human serine-racemase holoenzyme structure included its bound pyridoxal-phosphate cofactor.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3ea2d19a-b88a-531e-9cd3-a993735143de","slug":"srr","display_name":"Human serine racemase / SRR","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7f3bf9f5-b1b1-5381-baa6-72800ceb5436","slug":"d-serine","display_name":"D-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified human SRR crystal structure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Structural cofactor binding does not establish dietary B6 control of human D-aspartate or an effective supplementation threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Vitamin B6-derived PLP is part of the shared racemase machinery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Conformational flexibility within the small domain of human serine racemase. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32039887/ · DOI 10.1107/S2053230X20001193","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a49f9fe5-f275-555f-bc50-92a0a237913f","evidence_kind":"source_excerpt","locator":"Lines 56-62","start_line":56,"end_line":62,"excerpt":"## d-aspartate-srr-plp\nVitamin B6-derived PLP is part of the shared racemase machinery.\nThe 1.89-angstrom human serine-racemase holoenzyme structure included its bound pyridoxal-phosphate cofactor.\nModel: Purified human SRR crystal structure.\nLimitations: Structural cofactor binding does not establish dietary B6 control of human D-aspartate or an effective supplementation threshold.\nEvidence access: Primary abstract\nConformational flexibility within the small domain of human serine racemase. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32039887/ · DOI 10.1107/S2053230X20001193","model_system":"Purified human SRR crystal structure.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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