{"id":"b2989029-1544-5b2a-a2b7-ac6e21ac10ae","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mor-blockade","predicate":"blockade_prevents","statement":"Mu-opioid-receptor blockade with beta-funaltrexamine inhibited the myricetin-associated improvements in insulin resistance and signaling.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"aaf63be4-eac9-52c6-8b47-e696341f6e74","mechanism_event_label":"Blocking a receptor disrupted the response to another compound.","subject":{"id":"3c225e65-2cb3-5cd9-a26d-cce9cac32e8a","slug":"rat-oprm1","display_name":"Rat mu-opioid receptor / Oprm1","entity_type_key":"protein"},"object":{"id":"5ce56e11-3700-568c-871a-1b0c0b37c5d6","slug":"rat-myricetin-insulin-response","display_name":"Rat myricetin-associated insulin-sensitivity response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"aaf63be4-eac9-52c6-8b47-e696341f6e74","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mor-blockade-event","event_type":"observed_relationship","label":"Blocking a receptor disrupted the response to another compound.","description":"Mu-opioid-receptor blockade with beta-funaltrexamine inhibited the myricetin-associated improvements in insulin resistance and signaling.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3c225e65-2cb3-5cd9-a26d-cce9cac32e8a","slug":"rat-oprm1","display_name":"Rat mu-opioid receptor / Oprm1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5ce56e11-3700-568c-871a-1b0c0b37c5d6","slug":"rat-myricetin-insulin-response","display_name":"Rat myricetin-associated insulin-sensitivity response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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