{"id":"b28f8410-b322-56a5-9ffe-6c5ca650307d","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-brain-osmolytes","predicate":"withdrawal_after_hyponatremia_slowly_restores","statement":"Most organic osmolytes required five or more days to recover; glutamate was an exception that recovered within 24 hours.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c332a54c-eb15-5e66-af58-e9159cf640ef","mechanism_event_label":"Different brain solutes adapt on different timelines.","subject":{"id":"30736602-0f64-5aaf-896c-079e7c44a26b","slug":"ddavp","display_name":"Desmopressin / dDAVP","entity_type_key":"small_molecule"},"object":{"id":"689bd31f-93f2-5006-8238-bdae7da3bd78","slug":"brain-organic-osmolyte-content","display_name":"Brain organic osmolyte content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c332a54c-eb15-5e66-af58-e9159cf640ef","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-brain-osmolytes-event","event_type":"biochemical_relationship","label":"Different brain solutes adapt on different timelines.","description":"Most organic osmolytes required five or more days to recover; glutamate was an exception that recovered within 24 hours.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"86597b91-1e58-5669-a5a0-8357b5d31ab6","slug":"brain-organic-osmolytes","display_name":"Brain organic osmolytes (individual solutes and exceptions specified)","entity_type_key":"chemical_species"},"role":"measured_pool","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"explicit_exception","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"30736602-0f64-5aaf-896c-079e7c44a26b","slug":"ddavp","display_name":"Desmopressin / dDAVP","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"689bd31f-93f2-5006-8238-bdae7da3bd78","slug":"brain-organic-osmolyte-content","display_name":"Brain organic osmolyte content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/8096428.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7f7a7712c9e952343e279ae89e0d1051857c4188820819def597a430fdaf9e4c\", \"start_char\": 0, \"end_char\": 1587, \"text_sha256\": \"7f7a7712c9e952343e279ae89e0d1051857c4188820819def597a430fdaf9e4c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sustained dDAVP-induced hyponatremia followed by withdrawal and tissue measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"14 days hyponatremia; sodium rose from 104 to 139 mmol/L over 24 hours after withdrawal","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Extreme experimental correction; records tissue reaccumulation, not a safe human correction rate or direct proof of myelin injury in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Different brain solutes adapt on different timelines.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p8096428] Rapid correction of hyponatremia produces differential effects on brain osmolyte and electrolyte reaccumulation in rats. (1993). https://pubmed.ncbi.nlm.nih.gov/8096428/ DOI: 10.1016/0006-8993(93)91564-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain water, electrolytes and organic osmolytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"09d345e4-d34e-501e-9bad-45c85c33666c","evidence_kind":"source_excerpt","locator":"Lines 1032-1043","start_line":1032,"end_line":1043,"excerpt":"### sodium-brain-osmolytes\nMost organic osmolytes required five or more days to recover; glutamate was an exception that recovered within 24 hours.\nCondition category: biomarker_context\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Different brain solutes adapt on different timelines.\norganism: Rat\ntissue_or_cell_type: Brain water, electrolytes and organic osmolytes\nexperimental_model: Sustained dDAVP-induced hyponatremia followed by withdrawal and tissue measurements\nlimitations: Extreme experimental correction; records tissue reaccumulation, not a safe human correction rate or direct proof of myelin injury in this study.\nexposure: 14 days hyponatremia; sodium rose from 104 to 139 mmol/L over 24 hours after withdrawal\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/8096428.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7f7a7712c9e952343e279ae89e0d1051857c4188820819def597a430fdaf9e4c\", \"start_char\": 0, \"end_char\": 1587, \"text_sha256\": \"7f7a7712c9e952343e279ae89e0d1051857c4188820819def597a430fdaf9e4c\"}\n[sodium-p8096428] Rapid correction of hyponatremia produces differential effects on brain osmolyte and electrolyte reaccumulation in rats. (1993). https://pubmed.ncbi.nlm.nih.gov/8096428/ DOI: 10.1016/0006-8993(93)91564-9","model_system":"Sustained dDAVP-induced hyponatremia followed by withdrawal and tissue measurements","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sodium-p8096428] Rapid correction of hyponatremia produces differential effects on brain osmolyte and electrolyte reaccumulation in rats. (1993). https://pubmed.ncbi.nlm.nih.gov/8096428/ DOI: 10.1016/0006-8993(93)91564-9","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c260cd7b-beb0-5113-a198-69ec8fd4492c","stable_key":"import-195e8b84-ca5a-591a-a045-c55c53c8a01c","title":"Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"684f65cf0661c18395831ade4b02bb24d5e66c568f0d00a3471600eaf5d4d1c6","revision_id":"39866f04-3052-5f59-bd95-6806c5490875","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}