{"id":"b21a35e8-f3ac-5bc8-bdbb-d15920d177f4","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-pth-inhibition-depends-on-calcium","predicate":"inhibits-conditionally","statement":"In intact rat glands, raising Mg from 0.5 to 2 mM suppressed PTH most clearly at moderately low Ca; suppression was small or absent at normal-high Ca and diminished again at very low Ca.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"87f8679f-372e-5f32-b5b4-841c2ba6c66e","mechanism_event_label":"How much extra Mg reduces PTH depends on the calcium signal already reaching the gland.","subject":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"object":{"id":"003d1a6f-e672-5a4e-b78b-fac58daaa987","slug":"pth-secretion","display_name":"Parathyroid hormone secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"87f8679f-372e-5f32-b5b4-841c2ba6c66e","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-pth-inhibition-depends-on-calcium-event","event_type":"biochemical_relationship","label":"How much extra Mg reduces PTH depends on the calcium signal already reaching the gland.","description":"In intact rat glands, raising Mg from 0.5 to 2 mM suppressed PTH most clearly at moderately low Ca; suppression was small or absent at normal-high Ca and diminished again at very low Ca.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"conditioning extracellular signal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"secreted hormone","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"003d1a6f-e672-5a4e-b78b-fac58daaa987","slug":"pth-secretion","display_name":"Parathyroid hormone secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"magnesium -> PTH -> calcium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Intact rat parathyroid glands in graded Ca/Mg media","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"An ex-vivo concentration response, not a human threshold; very high 5 mM Mg produced broader suppression.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"How much extra Mg reduces PTH depends on the calcium signal already reaching the gland.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[rodriguez-ortiz-2014-pth-context] Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration (2014). https://pubmed.ncbi.nlm.nih.gov/24103811/ DOI: 10.1093/ndt/gft400","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Parathyroid gland","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d8b93b71-9cda-5e03-9908-c0607e9b4d65","evidence_kind":"source_excerpt","locator":"Lines 277-287","start_line":277,"end_line":287,"excerpt":"### mg-pth-inhibition-depends-on-calcium\nIn intact rat glands, raising Mg from 0.5 to 2 mM suppressed PTH most clearly at moderately low Ca; suppression was small or absent at normal-high Ca and diminished again at very low Ca.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: How much extra Mg reduces PTH depends on the calcium signal already reaching the gland.\norganism: Rattus norvegicus\ntissue_or_cell_type: Parathyroid gland\nexperimental_model: Intact rat parathyroid glands in graded Ca/Mg media\nlimitations: An ex-vivo concentration response, not a human threshold; very high 5 mM Mg produced broader suppression.\ncross_nutrient: magnesium -> PTH -> calcium\n[rodriguez-ortiz-2014-pth-context] Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration (2014). https://pubmed.ncbi.nlm.nih.gov/24103811/ DOI: 10.1093/ndt/gft400","model_system":"Intact rat parathyroid glands in graded Ca/Mg media","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [rodriguez-ortiz-2014-pth-context] Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration (2014). https://pubmed.ncbi.nlm.nih.gov/24103811/ DOI: 10.1093/ndt/gft400","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}