{"id":"b1f8dc04-2288-5dcb-b940-f9169d43c858","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-mouse-fertility","predicate":"improves_tested","statement":"Two or four weeks of 20 mM sodium D-aspartate in drinking water improved sperm quality and fertilizing performance in young/adult B6N mice without increasing sperm concentration.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a562dd65-6d34-5ae1-aa7f-b64d923d8292","mechanism_event_label":"Quality and sperm number were different outcomes.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"0f9b9370-3c8f-5695-9bda-67aa5b152193","slug":"mouse-sperm-ivf-performance","display_name":"Mouse sperm quality and IVF performance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a562dd65-6d34-5ae1-aa7f-b64d923d8292","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-mouse-fertility-event","event_type":"observed_relationship","label":"Quality and sperm number were different outcomes.","description":"Two or four weeks of 20 mM sodium D-aspartate in drinking water improved sperm quality and fertilizing performance in young/adult B6N mice without increasing sperm concentration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0f9b9370-3c8f-5695-9bda-67aa5b152193","slug":"mouse-sperm-ivf-performance","display_name":"Mouse sperm quality and IVF performance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Male mice aged 9 or 16 weeks at study end; frozen sperm, IVF and birth outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal reproductive/cryobanking experiment; does not establish human infertility treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Quality and sperm number were different outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Oral D-Aspartate Treatment Improves Sperm Fertility in Both Young and Adult B6N Mice. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35681815/ · DOI 10.3390/ani12111350","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f4c1c86c-40cd-5ce3-a932-e999eae717df","evidence_kind":"source_excerpt","locator":"Lines 408-414","start_line":408,"end_line":414,"excerpt":"## d-aspartate-mouse-fertility\nQuality and sperm number were different outcomes.\nTwo or four weeks of 20 mM sodium D-aspartate in drinking water improved sperm quality and fertilizing performance in young/adult B6N mice without increasing sperm concentration.\nModel: Male mice aged 9 or 16 weeks at study end; frozen sperm, IVF and birth outcomes.\nLimitations: Animal reproductive/cryobanking experiment; does not establish human infertility treatment.\nEvidence access: Primary abstract\nOral D-Aspartate Treatment Improves Sperm Fertility in Both Young and Adult B6N Mice. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35681815/ · DOI 10.3390/ani12111350","model_system":"Male mice aged 9 or 16 weeks at study end; frozen sperm, IVF and birth outcomes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0a86a1008edb8a69dcc79409e76e3fd5ce59b0747be8cae8f21e43f871e76248","revision_id":"a1de4b66-263d-5452-8ed8-df853afba030","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}