{"id":"b1df8588-a651-5407-aba9-6f8783a18af6","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-nsaid-clearance","predicate":"increases","statement":"Indomethacin raised plasma lithium while lowering renal lithium clearance in seven studied people.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"475eddbf-0d2c-5144-9a64-6fe79fa2ed05","mechanism_event_label":"A medicine can raise lithium exposure by slowing its removal.","subject":{"id":"b4ad67ed-ff1f-5c41-a6a4-040205a3bdf3","slug":"indomethacin","display_name":"Indomethacin","entity_type_key":"small_molecule"},"object":{"id":"57835bde-69fc-5cc2-b68e-1254c4db4da6","slug":"human-serum-lithium","display_name":"Human serum lithium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"475eddbf-0d2c-5144-9a64-6fe79fa2ed05","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-nsaid-clearance-event","event_type":"observed_relationship","label":"A medicine can raise lithium exposure by slowing its removal.","description":"Indomethacin raised plasma lithium while lowering renal lithium clearance in seven studied people.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b4ad67ed-ff1f-5c41-a6a4-040205a3bdf3","slug":"indomethacin","display_name":"Indomethacin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57835bde-69fc-5cc2-b68e-1254c4db4da6","slug":"human-serum-lithium","display_name":"Human serum lithium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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