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This does not establish that inositol supplements repair selenium-dependent receptor failure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Inositol research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"inositol","display_name":"Inositol (stereoisomer family)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mouse immune cells and mammalian cell models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Impairing the modification enzyme weakened the calcium-release response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ino-p25368151] Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. (2014). https://pubmed.ncbi.nlm.nih.gov/25368151/ DOI: 10.1073/pnas.1417176111","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"ER-associated IP3 receptor machinery","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1c3b3c53-70f2-5a20-800d-8a8101ef1957","evidence_kind":"source_excerpt","locator":"Lines 1107-1118","start_line":1107,"end_line":1118,"excerpt":"### ino-dhhc6-flux\nDHHC6 knockdown reduced IP3R expression and IP3R-dependent calcium flux.\nCondition category: machinery_impairment\nnutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Impairing the modification enzyme weakened the calcium-release response.\norganism: Mouse immune cells and mammalian cell models\ntissue_or_cell_type: ER-associated IP3 receptor machinery\nexperimental_model: Immune-cell perturbation, co-immunoprecipitation and palmitoylation assays\nlimitations: Selenium limitation and genetic deletion are distinct. This does not establish that inositol supplements repair selenium-dependent receptor failure.\nexposure: Selk deletion, low-selenium media, DHHC6 knockdown and IP3R cysteine mutants\nevidence_span: {\"source_cache\": \"artifacts/inositol-research/25368151.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"84452ee9a1f04bf54aba8030e5384d46a1dafdbb460281fd99c244e57d6644d9\", \"start_char\": 0, \"end_char\": 1873, \"text_sha256\": \"84452ee9a1f04bf54aba8030e5384d46a1dafdbb460281fd99c244e57d6644d9\"}\n[ino-p25368151] Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. (2014). https://pubmed.ncbi.nlm.nih.gov/25368151/ DOI: 10.1073/pnas.1417176111","model_system":"Immune-cell perturbation, co-immunoprecipitation and palmitoylation assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ino-p25368151] Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. (2014). https://pubmed.ncbi.nlm.nih.gov/25368151/ DOI: 10.1073/pnas.1417176111","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d590c659-b774-50e6-9f1d-aff61d5f7c9c","stable_key":"import-e69ef6a0-0e23-5eac-aca1-cf333781b962","title":"Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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