{"id":"b150b13c-1430-577e-a683-aac87ff7fad4","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-kir21-functional-hyperemia","predicate":"contributes_to","statement":"Endothelial Kir2.1 deletion reduced whisker-stimulation cerebral blood-flow responses by roughly half.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ff0fd4a7-2095-5dc8-b512-1c656fa78c2e","mechanism_event_label":"This potassium-sensing pathway contributed to activity-linked blood supply but did not account for all of it.","subject":{"id":"416f3f9e-2f1f-5d0e-9650-628d3c0d05cb","slug":"kcnj2","display_name":"KCNJ2 / Kir2.1","entity_type_key":"protein"},"object":{"id":"3c641d48-fcc4-5914-bad5-5a939da83126","slug":"cerebral-functional-hyperemia","display_name":"Cerebral functional hyperemia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ff0fd4a7-2095-5dc8-b512-1c656fa78c2e","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-kir21-functional-hyperemia-event","event_type":"biochemical_relationship","label":"This potassium-sensing pathway contributed to activity-linked blood supply but did not account for all of it.","description":"Endothelial Kir2.1 deletion reduced whisker-stimulation cerebral blood-flow responses by roughly half.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"local_signal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"416f3f9e-2f1f-5d0e-9650-628d3c0d05cb","slug":"kcnj2","display_name":"KCNJ2 / Kir2.1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3c641d48-fcc4-5914-bad5-5a939da83126","slug":"cerebral-functional-hyperemia","display_name":"Cerebral functional hyperemia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Mouse endothelial knockout and cortical flow measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Residual responses require other contributors; no cognitive or dietary outcome tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This potassium-sensing pathway contributed to activity-linked blood supply but did not account for all of it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-longden2017] Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow (2017). https://pubmed.ncbi.nlm.nih.gov/28319610/ DOI: 10.1038/nn.4533","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cerebral microcirculation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3f71f955-e69a-509a-9861-ad514a9311f3","evidence_kind":"source_excerpt","locator":"Lines 1616-1625","start_line":1616,"end_line":1625,"excerpt":"### k-kir21-functional-hyperemia\nEndothelial Kir2.1 deletion reduced whisker-stimulation cerebral blood-flow responses by roughly half.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This potassium-sensing pathway contributed to activity-linked blood supply but did not account for all of it.\norganism: Mus musculus\ntissue_or_cell_type: Cerebral microcirculation\nexperimental_model: Mouse endothelial knockout and cortical flow measurement.\nlimitations: Residual responses require other contributors; no cognitive or dietary outcome tested.\n[k-longden2017] Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow (2017). https://pubmed.ncbi.nlm.nih.gov/28319610/ DOI: 10.1038/nn.4533","model_system":"Mouse endothelial knockout and cortical flow measurement.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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