{"id":"b1478a92-5e34-5565-bf92-eac53a6153d8","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-gatm-taurine","predicate":"produces","statement":"Purified human GATM transferred an amidino group from arginine to taurine, producing taurocyamine in vitro.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d44c1795-3379-52ea-9db8-5cc7a366615c","mechanism_event_label":"Creatine-synthesis machinery also accepts a taurine-related side reaction.","subject":{"id":"c8ab5c45-4253-5dd5-be9c-2fcdfa69ac3a","slug":"gatm","display_name":"Human glycine amidinotransferase AGAT / GATM","entity_type_key":"protein"},"object":{"id":"8a2c2166-001d-5945-ac81-a303d5795133","slug":"taurocyamine","display_name":"Taurocyamine / guanidinotaurine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"d44c1795-3379-52ea-9db8-5cc7a366615c","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-gatm-taurine-event","event_type":"observed_relationship","label":"Creatine-synthesis machinery also accepts a taurine-related side reaction.","description":"Purified human GATM transferred an amidino group from arginine to taurine, producing taurocyamine in vitro.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c8ab5c45-4253-5dd5-be9c-2fcdfa69ac3a","slug":"gatm","display_name":"Human glycine amidinotransferase AGAT / GATM","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8a2c2166-001d-5945-ac81-a303d5795133","slug":"taurocyamine","display_name":"Taurocyamine / guanidinotaurine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ae2dddf4-ce04-57e3-8a06-7ed9fdc24554","slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""},{"entity":{"id":"c715e48e-42db-5fac-b4a4-c1285a68d085","slug":"ornithine","display_name":"L-Ornithine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":6,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text; Figure 4B","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human GATM substrate comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Taurine is a secondary substrate in this assay; tissue flux and clinically important depletion were not established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Agmatine Sulfate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Creatine-synthesis machinery also accepts a taurine-related side reaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Guanidino acid hydrolysis by the human enzyme annotated as agmatinase. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36543883/ · DOI 10.1038/s41598-022-26655-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c5e97670-3818-5167-8f34-f5c47300f6db","evidence_kind":"source_excerpt","locator":"Lines 188-194","start_line":188,"end_line":194,"excerpt":"## agmatine-sulfate-gatm-taurine\nCreatine-synthesis machinery also accepts a taurine-related side reaction.\nPurified human GATM transferred an amidino group from arginine to taurine, producing taurocyamine in vitro.\nModel: Recombinant human GATM substrate comparison.\nLimitations: Taurine is a secondary substrate in this assay; tissue flux and clinically important depletion were not established.\nEvidence access: Primary full text; Figure 4B\nGuanidino acid hydrolysis by the human enzyme annotated as agmatinase. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36543883/ · DOI 10.1038/s41598-022-26655-4","model_system":"Recombinant human GATM substrate comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e0426971-7d13-51c9-8354-6547b664f1cf","stable_key":"import-220adaab-10d8-5c4e-a3f5-a48700ea794d","title":"Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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