{"id":"b1123ec5-dfbf-5c3e-a72e-2cb0e1c76cac","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-permeability-endotoxin","predicate":"increases","statement":"Patients with chronic alcohol abuse showed increased intestinal permeability to macromolecules and endotoxaemia, varying across stages of alcohol-induced liver disease.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"77703ea7-9501-57a2-97f5-a9e994cd9225","mechanism_event_label":"The gut wall leaks and bacterial fragments reach the blood.","subject":{"id":"38692dc7-dbe9-5295-bcb7-145c768b28a3","slug":"alcohol-consumption","display_name":"Habitual alcohol consumption","entity_type_key":"cellular_process"},"object":{"id":"e653568c-ba57-5379-80a9-18ae320391b6","slug":"intestinal-permeability","display_name":"Intestinal permeability to macromolecules","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"77703ea7-9501-57a2-97f5-a9e994cd9225","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-permeability-endotoxin-event","event_type":"observed_intervention","label":"The gut wall leaks and bacterial fragments reach the blood.","description":"Patients with chronic alcohol abuse showed increased intestinal permeability to macromolecules and endotoxaemia, varying across stages of alcohol-induced liver disease.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"517ec73b-2632-50a0-ad56-aa98869efe63","slug":"plasma-endotoxin","display_name":"Circulating endotoxin concentration","entity_type_key":"cellular_process"},"role":"downstream_measure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38692dc7-dbe9-5295-bcb7-145c768b28a3","slug":"alcohol-consumption","display_name":"Habitual alcohol consumption","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e653568c-ba57-5379-80a9-18ae320391b6","slug":"intestinal-permeability","display_name":"Intestinal permeability to macromolecules","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/10845660.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0342f8e351dde29e075eaf2d1920f26d1e8ef9d9a704947dc6c08f6f5fde846d\", \"start_char\": 0, \"end_char\": 1618, \"text_sha256\": \"0342f8e351dde29e075eaf2d1920f26d1e8ef9d9a704947dc6c08f6f5fde846d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Intestinal permeability and endotoxin measurement across stages of alcohol-induced liver disease","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chronic alcohol abuse, staged by liver disease severity","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Human observational staging. It shows permeability tracks disease stage; it cannot establish which came first.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The gut wall leaks and bacterial fragments reach the blood.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p10845660] Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. (2000). https://pubmed.ncbi.nlm.nih.gov/10845660/ DOI: 10.1016/s0168-8278(00)80242-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine and blood","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8e002542-b53a-5792-9ee9-7886bf4d3e6c","evidence_kind":"source_excerpt","locator":"Lines 462-473","start_line":462,"end_line":473,"excerpt":"### alcohol-permeability-endotoxin\nPatients with chronic alcohol abuse showed increased intestinal permeability to macromolecules and endotoxaemia, varying across stages of alcohol-induced liver disease.\nCondition category: normal\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: The gut wall leaks and bacterial fragments reach the blood.\norganism: Human\ntissue_or_cell_type: Intestine and blood\nexperimental_model: Intestinal permeability and endotoxin measurement across stages of alcohol-induced liver disease\nlimitations: Human observational staging. It shows permeability tracks disease stage; it cannot establish which came first.\nexposure: Chronic alcohol abuse, staged by liver disease severity\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/10845660.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0342f8e351dde29e075eaf2d1920f26d1e8ef9d9a704947dc6c08f6f5fde846d\", \"start_char\": 0, \"end_char\": 1618, \"text_sha256\": \"0342f8e351dde29e075eaf2d1920f26d1e8ef9d9a704947dc6c08f6f5fde846d\"}\n[alcohol-p10845660] Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. (2000). https://pubmed.ncbi.nlm.nih.gov/10845660/ DOI: 10.1016/s0168-8278(00)80242-1","model_system":"Intestinal permeability and endotoxin measurement across stages of alcohol-induced liver disease","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [alcohol-p10845660] Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. (2000). https://pubmed.ncbi.nlm.nih.gov/10845660/ DOI: 10.1016/s0168-8278(00)80242-1","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4b310db0-1387-548c-9e3d-6d2ed634b2cd","stable_key":"import-fcc4fa9c-4dc8-5566-b780-1a486c4d3e72","title":"Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"cb7e8dc390e8bf302cd5e230cadff6ce9847b4aad8a3691a308964d93ba59a85","revision_id":"4b344e1e-4129-579c-a058-50262b03f9a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}