{"id":"b10b7aeb-1ab1-5c68-8d03-0512f5bc883e","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-phs-cardiovascular","predicate":"does_not_significantly_reduce","statement":"Vitamin E did not reduce major cardiovascular events in PHS II (HR 1.01, 95% CI 0.90–1.13).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ce41cf22-4c37-577d-bd99-ade70d3376ba","mechanism_event_label":"The tested vitamin E regimen did not prevent major cardiovascular events in these men.","subject":{"id":"1e078aed-0416-5fe7-8b8b-36bc2ca8ab7a","slug":"all-rac-alpha-tocopherol","display_name":"All-rac-alpha-tocopherol","entity_type_key":"small_molecule"},"object":{"id":"d8725325-698d-50ab-9079-acf07d86cf9f","slug":"major-cardiovascular-events","display_name":"Major cardiovascular events","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ce41cf22-4c37-577d-bd99-ade70d3376ba","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-phs-cardiovascular-event","event_type":"observed_intervention","label":"The tested vitamin E regimen did not prevent major cardiovascular events in these men.","description":"Vitamin E did not reduce major cardiovascular events in PHS II (HR 1.01, 95% CI 0.90–1.13).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"factorial_trial_agent","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1e078aed-0416-5fe7-8b8b-36bc2ca8ab7a","slug":"all-rac-alpha-tocopherol","display_name":"All-rac-alpha-tocopherol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d8725325-698d-50ab-9079-acf07d86cf9f","slug":"major-cardiovascular-events","display_name":"Major cardiovascular events","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Physicians Health Study II randomized factorial trial; 14641 male US physicians aged at least 50","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Synthetic alpha-tocopherol 400 IU on alternate days, with factorial vitamin C 500 mg/day; mean follow-up 8 years.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mostly primary prevention in male physicians; historical regimen is not nutritional repletion. Primary Methods specify synthetic alpha-tocopherol; no unverified ester identity is attached.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The tested vitamin E regimen did not prevent major cardiovascular events in these men.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-phs2008] Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. 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Primary Methods specify synthetic alpha-tocopherol; no unverified ester identity is attached.\nexposure: Synthetic alpha-tocopherol 400 IU on alternate days, with factorial vitamin C 500 mg/day; mean follow-up 8 years.\ncross_nutrient: true\n[e-clin-phs2008] Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. (2008). https://pubmed.ncbi.nlm.nih.gov/18997197/ DOI: 10.1001/jama.2008.600","model_system":"Physicians Health Study II randomized factorial trial; 14641 male US physicians aged at least 50","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-phs2008] Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. 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