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(1998). https://pubmed.ncbi.nlm.nih.gov/9843739/ DOI: 10.1152/ajpendo.1998.275.6.e974","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Skeletal muscle and limb circulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bbfb2573-f9d8-5d35-9f72-bfa88a2e3b03","evidence_kind":"source_excerpt","locator":"Lines 451-462","start_line":451,"end_line":462,"excerpt":"### creatine-insulin-flow-boundary\nLimb blood-flow differences did not explain the insulin-associated increase in muscle creatine accumulation.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Greater delivery through the bloodstream alone did not account for the measured uptake effect.\norganism: Seven men\ntissue_or_cell_type: Skeletal muscle and limb circulation\nexperimental_model: Insulin-clamp dose experiment with creatine administration\nlimitations: High physiological or supraphysiological insulin exposure; transport stimulation was inferred, not a direct SLC6A8 molecular assay.\nexposure: 12.4 g creatine with four insulin infusion conditions\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/9843739.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"405040e7e3d900e06a7f83a43c660ae040e7c95c53c96cd9159a766dee9fdda0\", \"start_char\": 0, \"end_char\": 1214, \"text_sha256\": \"405040e7e3d900e06a7f83a43c660ae040e7c95c53c96cd9159a766dee9fdda0\"}\n[creatine-p9843739] Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. 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