{"id":"b07282f8-4f34-56a2-9712-945113553b48","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:metfts-engineered","predicate":"reported_relationship","statement":"Experimental met-FTS gene delivery expresses an engineered analogue; it does not identify the native human FTS precursor gene.","claim_class":"identity","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"1f2fdd4e-8987-5817-9fc7-a964de84be3e","mechanism_event_label":"Experimental met-FTS gene delivery expresses an engineered analogue; it does not identify the native human FTS precursor gene.","subject":{"id":"9344cae9-4005-5e00-bb3f-9ac0d6feabc3","slug":"met-fts","display_name":"Engineered methionine-FTS analogue","entity_type_key":"peptide"},"object":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"evidence_count":1,"mechanism_event":{"id":"1f2fdd4e-8987-5817-9fc7-a964de84be3e","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:metfts-engineered-event","event_type":"experimental_observation","label":"Experimental met-FTS gene delivery expresses an engineered analogue; it does not identify the native human FTS precursor gene.","description":"Identification of the peptide does not identify its full native biosynthetic pathway. No sufficiently established endogenous precursor gene and processing sequence was verified in this review. The synthetic **met-FTS** construct used for experimental gene delivery is an engineered analogue; successful expression is not discovery of the native human gene. [Synthetic expression study](https://doi.org/10.1038/sj.gt.3302775)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9344cae9-4005-5e00-bb3f-9ac0d6feabc3","slug":"met-fts","display_name":"Engineered methionine-FTS analogue","entity_type_key":"peptide"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary bibliographic record and abstract checked; full methods/figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Engineered synthetic expression study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Experimental met-FTS gene delivery expresses an engineered analogue; it does not identify the native human FTS precursor gene.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Gene therapy for long-term restoration of circulating thymulin in thymectomized mice and rats. | 2006 | DOI 10.1038/sj.gt.3302775 | PMID 16617301 | https://doi.org/10.1038/sj.gt.3302775","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 50-50; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"063e764a-1faa-5c09-b430-ebf15deac6d8","evidence_kind":"source_excerpt","locator":"Lines 50-50","start_line":50,"end_line":50,"excerpt":"Identification of the peptide does not identify its full native biosynthetic pathway. No sufficiently established endogenous precursor gene and processing sequence was verified in this review. The synthetic **met-FTS** construct used for experimental gene delivery is an engineered analogue; successful expression is not discovery of the native human gene. [Synthetic expression study](https://doi.org/10.1038/sj.gt.3302775)","model_system":"Engineered synthetic expression study.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e1871d49-9c6b-547b-a1bb-6e2b9270ca89","stable_key":"import-18100170-a014-51c3-adeb-9dab4162b8cc","title":"Thymulin: detailed mechanisms of action (reviewed 3 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"6e8ed0d7a5e23fc822f2ab418e0c4fb2411c01fcaa330039e8d7d93218cacc88","revision_id":"8c0e3449-9bbd-57c0-bb5e-de83f044f2ac","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}