{"id":"b053cf2f-a752-5ff4-80b2-ce9873b3f9d6","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-platelet-readouts","predicate":"associated_with","statement":"Proteomic analyses and follow-up assays indicated platelet degranulation and complement/coagulation-associated changes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0cf660cb-4329-5020-9c70-53f4ba90a917","mechanism_event_label":"The response included blood and vascular pathways.","subject":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"object":{"id":"f0bdfcc6-6b00-5b37-88b3-80ffe5b42c76","slug":"platelet-degranulation-signature","display_name":"Platelet degranulation and coagulation-associated readouts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0cf660cb-4329-5020-9c70-53f4ba90a917","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-platelet-readouts-event","event_type":"observed_relationship","label":"The response included blood and vascular pathways.","description":"Proteomic analyses and follow-up assays indicated platelet degranulation and complement/coagulation-associated changes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f0bdfcc6-6b00-5b37-88b3-80ffe5b42c76","slug":"platelet-degranulation-signature","display_name":"Platelet degranulation and coagulation-associated readouts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same prolonged-fasting cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Pathway readouts do not prove that participants developed thrombosis or cardiovascular disease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"The response included blood and vascular pathways.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Prolonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40268190/ · DOI 10.1016/j.molmet.2025.102152","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dbebeb1b-54dd-5ea6-8428-b8ecb6bbe28a","evidence_kind":"source_excerpt","locator":"Lines 440-446","start_line":440,"end_line":446,"excerpt":"## fast-platelet-readouts\nThe response included blood and vascular pathways.\nProteomic analyses and follow-up assays indicated platelet degranulation and complement/coagulation-associated changes.\nModel: Same prolonged-fasting cohort.\nLimitations: Pathway readouts do not prove that participants developed thrombosis or cardiovascular disease.\nEvidence access: Primary abstract\nProlonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40268190/ · DOI 10.1016/j.molmet.2025.102152","model_system":"Same prolonged-fasting cohort.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}