{"id":"b030e8f5-d0f4-51a5-a509-45ae14a73e67","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-warburg-growth","predicate":"modulates","statement":"Butyrate stimulated proliferation in the tested oxidative settings but inhibited proliferation in cells undergoing the Warburg effect.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c68c868a-99a4-54d4-88eb-e55d8a8ad03a","mechanism_event_label":"One molecule produced opposite growth responses in different metabolic states.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"c7932557-5de9-5fb6-bf59-2ddff2434b70","slug":"human-butyrate-metabolic-growth-response","display_name":"Metabolism-dependent proliferation response to butyrate in human colonic cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c68c868a-99a4-54d4-88eb-e55d8a8ad03a","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-warburg-growth-event","event_type":"observed_relationship","label":"One molecule produced opposite growth responses in different metabolic states.","description":"Butyrate stimulated proliferation in the tested oxidative settings but inhibited proliferation in cells undergoing the Warburg effect.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c7932557-5de9-5fb6-bf59-2ddff2434b70","slug":"human-butyrate-metabolic-growth-response","display_name":"Metabolism-dependent proliferation response to butyrate in human colonic cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human noncancerous and cancerous colonic-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is an experimentally explained context difference, not a draft correction or an unexplained universal contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"One molecule produced opposite growth responses in different metabolic states.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23063526/ · DOI 10.1016/j.molcel.2012.08.033","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a6664dc0-153b-5f03-aa49-4ef7a1584516","evidence_kind":"source_excerpt","locator":"Lines 198-204","start_line":198,"end_line":204,"excerpt":"## butyrate-warburg-growth\nOne molecule produced opposite growth responses in different metabolic states.\nButyrate stimulated proliferation in the tested oxidative settings but inhibited proliferation in cells undergoing the Warburg effect.\nModel: Human noncancerous and cancerous colonic-cell experiments.\nLimitations: This is an experimentally explained context difference, not a draft correction or an unexplained universal contradiction.\nEvidence access: Primary abstract\nThe Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23063526/ · DOI 10.1016/j.molcel.2012.08.033","model_system":"Human noncancerous and cancerous colonic-cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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