{"id":"afe7ae1a-79b8-5954-aea6-57f7f16f7288","stable_key":"1fb6218a-60d1-55ea-87fe-07d15d0fc46f:rac1-supports-viral-f-protein-surface-expression","predicate":"supports","statement":"Loss of Rac1 activity strongly inhibited respiratory syncytial virus through a decrease in F protein surface expression.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7ca4d941-13a3-58b5-b027-2e2b3ae2ccf7","mechanism_event_label":"Loss of Rac1 activity strongly inhibited respiratory syncytial virus through a decrease in F protein surface expression.","subject":{"id":"8a96d7c7-d28d-5615-94a7-3c397bed8f9d","slug":"rac1","display_name":"RAC1","entity_type_key":"protein"},"object":{"id":"345bef1c-9f95-5237-9562-4307b8cbf5b5","slug":"rsv-f-protein-surface-expression","display_name":"Respiratory syncytial virus F protein surface expression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7ca4d941-13a3-58b5-b027-2e2b3ae2ccf7","stable_key":"1fb6218a-60d1-55ea-87fe-07d15d0fc46f:rac1-supports-viral-f-protein-surface-expression-event","event_type":"observed_relationship","label":"Loss of Rac1 activity strongly inhibited respiratory syncytial virus through a decrease in F protein surface expression.","description":"Loss of Rac1 activity strongly inhibited respiratory syncytial virus through a decrease in F protein surface expression.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8a96d7c7-d28d-5615-94a7-3c397bed8f9d","slug":"rac1","display_name":"RAC1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"345bef1c-9f95-5237-9562-4307b8cbf5b5","slug":"rsv-f-protein-surface-expression","display_name":"Respiratory syncytial virus F protein surface expression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ad6c0a7-3e19-57ac-a3f1-04b0c02e4d19","slug":"rho-gtpase-prenylation","display_name":"Prenylation of Rho-family GTPases","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cell culture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Rac1 activity loss under statin or geranylgeranyltransferase inhibition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rac1 was the strongest of the Rho-family GTPases assayed in that study; the others were not equivalent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human cell culture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Loss of Rac1 activity strongly inhibited respiratory syncytial virus through a decrease in F protein surface expression.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection. (2021). https://pubmed.ncbi.nlm.nih.gov/34716403/ DOI: 10.1038/s42003-021-02754-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Rho-family GTPase activity and viral fusion protein surface expression","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0bdff8b1-512c-59cd-b1ea-40c4f8528b2b","evidence_kind":"source_excerpt","locator":"Lines 100-109","start_line":100,"end_line":109,"excerpt":"## rac1-supports-viral-f-protein-surface-expression\nLoss of Rac1 activity strongly inhibited respiratory syncytial virus through a decrease in F protein surface expression.\nModel/species: Human cell culture\nTissue/system: Rho-family GTPase activity and viral fusion protein surface expression\nExposure: Rac1 activity loss under statin or geranylgeranyltransferase inhibition\nRoute: In vitro\nDuration: Not stated here\nLimits: Rac1 was the strongest of the Rho-family GTPases assayed in that study; the others were not equivalent.\nPrimary reference: Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection. (2021). https://pubmed.ncbi.nlm.nih.gov/34716403/ DOI: 10.1038/s42003-021-02754-2\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"a4431d8c-34d7-5db7-9edf-a35f68feba39","stable_key":"import-1fb6218a-60d1-55ea-87fe-07d15d0fc46f","title":"Atorvastatin: mechanism of action from target occupancy to isoprenoids, transport, muscle and metabolism (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Findings obtained with mevastatin, simvastatin or the statin class are recorded against those subjects. Study-specific citations, doses, negative findings and limitations retained. 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