{"id":"afb677b5-5fc1-55e2-9fe2-1e6a474c0ed1","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-camkk-block","predicate":"inhibition_reduces","statement":"STO609 reduced the mouse C2C12 AMPK response to 50 micromolar resveratrol but not to 300 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"691a1ad2-5706-5637-bdb5-510480560f39","mechanism_event_label":"Higher exposure can bypass the calcium-dependent kinase route.","subject":{"id":"0d88ff79-6df8-5e9c-b55b-a8aa1f4b5a90","slug":"mouse-camkk2","display_name":"Mouse CaMKK beta / Camkk2","entity_type_key":"protein"},"object":{"id":"871e74d6-6e9e-5e9c-9c6b-f269f59cb02a","slug":"mouse-ampk-complexes","display_name":"Mouse AMPK complexes","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"691a1ad2-5706-5637-bdb5-510480560f39","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-camkk-block-event","event_type":"observed_relationship","label":"Higher exposure can bypass the calcium-dependent kinase route.","description":"STO609 reduced the mouse C2C12 AMPK response to 50 micromolar resveratrol but not to 300 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0d88ff79-6df8-5e9c-b55b-a8aa1f4b5a90","slug":"mouse-camkk2","display_name":"Mouse CaMKK beta / Camkk2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"871e74d6-6e9e-5e9c-9c6b-f269f59cb02a","slug":"mouse-ampk-complexes","display_name":"Mouse AMPK complexes","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Pharmacological CaMKK inhibition; two resveratrol concentrations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Inhibitor specificity limits isoform-level certainty.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Higher exposure can bypass the calcium-dependent kinase route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"0829b391-f4b4-5d70-8cce-14ce6d1b7ee1","evidence_kind":"source_excerpt","locator":"Lines 262-268","start_line":262,"end_line":268,"excerpt":"## resveratrol-camkk-block\nHigher exposure can bypass the calcium-dependent kinase route.\nSTO609 reduced the mouse C2C12 AMPK response to 50 micromolar resveratrol but not to 300 micromolar.\nModel: Pharmacological CaMKK inhibition; two resveratrol concentrations.\nLimitations: Inhibitor specificity limits isoform-level certainty.\nEvidence access: Primary full text\nResveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22304913/ · DOI 10.1016/j.cell.2012.01.017","model_system":"Pharmacological CaMKK inhibition; two resveratrol concentrations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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