{"id":"af75c7f2-3810-5845-b611-a66754a016ce","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-skin-replication-null","predicate":"did_not_improve","statement":"Neither capsule nor paste showed improvement in visual minimal erythema dose over the ten-week UVB study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"806e0522-cdb6-5753-8ea9-8e1b731f5600","mechanism_event_label":"Skin protection was not a consistent result across protocols.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"285bddd3-7d1a-5cc6-ab96-6a485e6627f1","slug":"uv-minimal-erythema-dose","display_name":"Visually assessed UV minimal erythema dose","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"806e0522-cdb6-5753-8ea9-8e1b731f5600","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-skin-replication-null-event","event_type":"biochemical_relationship","label":"Skin protection was not a consistent result across protocols.","description":"Neither capsule nor paste showed improvement in visual minimal erythema dose over the ten-week UVB study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"285bddd3-7d1a-5cc6-ab96-6a485e6627f1","slug":"uv-minimal-erythema-dose","display_name":"Visually assessed UV minimal erythema dose","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/26024575.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"682051a8b59270407b327cf439145fec1ea55459fd3c6e8236b535f985442d00\", \"start_char\": 0, \"end_char\": 1667, \"text_sha256\": \"682051a8b59270407b327cf439145fec1ea55459fd3c6e8236b535f985442d00\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized comparative capsule-versus-paste study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ten weeks of capsule or tomato paste","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small study without an untreated placebo group; differs in UV spectrum and outcomes from the 2011 study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 20 enrolled; three withdrew after week four","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Skin protection was not a consistent result across protocols.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p26024575] Lycopene not in pill, nor in natura has photoprotective systemic effect. (2015). https://pubmed.ncbi.nlm.nih.gov/26024575/ DOI: 10.1007/s00403-015-1578-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"UVB-induced erythema and serum lycopene","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"88c32e79-7d99-5f26-81ef-58a6b2793043","evidence_kind":"source_excerpt","locator":"Lines 1235-1246","start_line":1235,"end_line":1246,"excerpt":"### lycopene-skin-replication-null\nNeither capsule nor paste showed improvement in visual minimal erythema dose over the ten-week UVB study.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Skin protection was not a consistent result across protocols.\norganism: Human, 20 enrolled; three withdrew after week four\ntissue_or_cell_type: UVB-induced erythema and serum lycopene\nexperimental_model: Randomized comparative capsule-versus-paste study\nlimitations: Small study without an untreated placebo group; differs in UV spectrum and outcomes from the 2011 study.\nexposure: Ten weeks of capsule or tomato paste\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/26024575.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"682051a8b59270407b327cf439145fec1ea55459fd3c6e8236b535f985442d00\", \"start_char\": 0, \"end_char\": 1667, \"text_sha256\": \"682051a8b59270407b327cf439145fec1ea55459fd3c6e8236b535f985442d00\"}\n[lycopene-p26024575] Lycopene not in pill, nor in natura has photoprotective systemic effect. 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