{"id":"af127edd-94d9-5145-be92-a9288289514a","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:plaque-reduction-did-not-track-lipid-lowering","predicate":"does_not_predict","statement":"The lipid-lowering seen in the nattokinase arm did not correlate with the reduction in intima-media thickness or plaque area.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"4eb7b768-856d-5cef-bb00-c557c172efdc","mechanism_event_label":"The lipid-lowering seen in the nattokinase arm did not correlate with the reduction in intima-media thickness or plaque area.","subject":{"id":"59b27f87-63a9-500e-9912-6c8863d9766b","slug":"blood-ldl-cholesterol","display_name":"Blood low-density lipoprotein cholesterol concentration","entity_type_key":"cellular_process"},"object":{"id":"b85ffd57-0433-5179-bb55-179b51fd155c","slug":"carotid-plaque-area","display_name":"Carotid plaque area","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4eb7b768-856d-5cef-bb00-c557c172efdc","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:plaque-reduction-did-not-track-lipid-lowering-event","event_type":"observed_intervention","label":"The lipid-lowering seen in the nattokinase arm did not correlate with the reduction in intima-media thickness or plaque area.","description":"Carotid imaging against blood lipids","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59b27f87-63a9-500e-9912-6c8863d9766b","slug":"blood-ldl-cholesterol","display_name":"Blood low-density lipoprotein cholesterol concentration","entity_type_key":"cellular_process"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b85ffd57-0433-5179-bb55-179b51fd155c","slug":"carotid-plaque-area","display_name":"Carotid plaque area","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"26 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human (39 nattokinase-arm completers)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nattokinase 6,000 FU per day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A within-arm correlation of r = 0.35 at p = 0.09, which is an absence of detected correlation in a small sample rather than established independence. The authors read it as showing a mechanism separate from lipid lowering.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human (39 nattokinase-arm completers)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The lipid-lowering seen in the nattokinase arm did not correlate with the reduction in intima-media thickness or plaque area.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. 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Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. 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