{"id":"aefc2e60-2a69-5779-a68d-ce9220c2fd79","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-adaptation-markers","predicate":"did_not_change_tested","statement":"Erythrocyte osmotic fragility, in-vitro erythrocyte 65Zn uptake, and leukocyte ZIP1 and ZnT1 expression did not respond to dietary zinc content in these experiments.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"8d8471ae-5756-5dcf-b5d1-e51c9706b7ae","mechanism_event_label":"Several candidate blood tests missed the dietary differences.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"1ca453e3-816b-563f-95f7-d2fa029e5519","slug":"dietary-zinc-biomarker-response","display_name":"Candidate biomarkers during dietary zinc adaptation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8d8471ae-5756-5dcf-b5d1-e51c9706b7ae","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-adaptation-markers-event","event_type":"observed_intervention","label":"Several candidate blood tests missed the dietary differences.","description":"Erythrocyte osmotic fragility, in-vitro erythrocyte 65Zn uptake, and leukocyte ZIP1 and ZnT1 expression did not respond to dietary zinc content in these experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1ca453e3-816b-563f-95f7-d2fa029e5519","slug":"dietary-zinc-biomarker-response","display_name":"Candidate biomarkers during dietary zinc adaptation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc exposure and the specifically measured response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/hunt2008.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"da28b136fa7271f3406a8cf55cc3e613a5e8749578c1ee662057ebe564df8995\", \"utf8_bytes\": 1647}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three controlled dietary experiments in 109 healthy adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ten diets: 4–29 mg zinc/day, phytate:zinc molar ratios 2–7 or 15–23, before and after 4 or 8 weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Dietary restriction and adaptation are not proof of clinical zinc deficiency. The reported 92% was an upper observed absorption value, not a mean.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Several candidate blood tests missed the dietary differences.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-hunt2008] Adaptation in human zinc absorption as influenced by dietary zinc and bioavailability. (2008). https://pubmed.ncbi.nlm.nih.gov/18469257/ DOI: 10.1093/ajcn/87.5.1336","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal absorption and candidate blood biomarkers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d9dbdf3a-dbcc-5c44-88c3-eaec4b4a37a2","evidence_kind":"source_excerpt","locator":"Lines 1332-1345","start_line":1332,"end_line":1345,"excerpt":"### zn-clin-adaptation-markers\nErythrocyte osmotic fragility, in-vitro erythrocyte 65Zn uptake, and leukocyte ZIP1 and ZnT1 expression did not respond to dietary zinc content in these experiments.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Several candidate blood tests missed the dietary differences.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal absorption and candidate blood biomarkers\nexperimental_model: Three controlled dietary experiments in 109 healthy adults\nlimitations: Dietary restriction and adaptation are not proof of clinical zinc deficiency. The reported 92% was an upper observed absorption value, not a mean.\nexposure: Ten diets: 4–29 mg zinc/day, phytate:zinc molar ratios 2–7 or 15–23, before and after 4 or 8 weeks.\ncross_nutrient: Zinc exposure and the specifically measured response.\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/hunt2008.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"da28b136fa7271f3406a8cf55cc3e613a5e8749578c1ee662057ebe564df8995\", \"utf8_bytes\": 1647}\n[zn-clin-hunt2008] Adaptation in human zinc absorption as influenced by dietary zinc and bioavailability. (2008). https://pubmed.ncbi.nlm.nih.gov/18469257/ DOI: 10.1093/ajcn/87.5.1336","model_system":"Three controlled dietary experiments in 109 healthy adults","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-hunt2008] Adaptation in human zinc absorption as influenced by dietary zinc and bioavailability. (2008). https://pubmed.ncbi.nlm.nih.gov/18469257/ DOI: 10.1093/ajcn/87.5.1336","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2e731dd54477ec1254e97df3323e1208d38f1375effed19252e71ab4f600d13a","revision_id":"c72258b9-ac09-5408-9d44-a921ad1f96a3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}