{"id":"aee9164a-1772-5fcd-8f34-41d93cdf6fdc","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-phosphocholine-recognition","predicate":"preferentially_interacts_with","statement":"NFS-rich silica strongly adsorbed zwitterionic phospholipid assemblies and disrupted their order more than negatively charged liposomes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0ee5422a-5e2a-5da5-825d-84a48157f32f","mechanism_event_label":"The phosphocholine headgroup creates a molecular link to membrane composition.","subject":{"id":"42c3c2f2-e2a2-5e81-b3de-f8b3374a31f2","slug":"silica-nearly-free-silanols","display_name":"Nearly free surface silanols on silica particles","entity_type_key":"chemical_species"},"object":{"id":"2f77ef6d-3ecd-5a80-9ca3-3cbea403d9fc","slug":"phosphatidylcholine","display_name":"Phosphatidylcholine","entity_type_key":"lipid"},"evidence_count":1,"mechanism_event":{"id":"0ee5422a-5e2a-5da5-825d-84a48157f32f","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-phosphocholine-recognition-event","event_type":"observed_relationship","label":"The phosphocholine headgroup creates a molecular link to membrane composition.","description":"NFS-rich silica strongly adsorbed zwitterionic phospholipid assemblies and disrupted their order more than negatively charged liposomes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"42c3c2f2-e2a2-5e81-b3de-f8b3374a31f2","slug":"silica-nearly-free-silanols","display_name":"Nearly free surface silanols on silica particles","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2f77ef6d-3ecd-5a80-9ca3-3cbea403d9fc","slug":"phosphatidylcholine","display_name":"Phosphatidylcholine","entity_type_key":"lipid"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b2d4231b-3893-5d4e-8b52-d0effdaa26c9","slug":"crystalline-silica","display_name":"Crystalline silica / quartz particles","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"5eb47f46-5727-5236-8e42-c2c85ed5c66a","slug":"amorphous-silica-particles","display_name":"Amorphous silica particles","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Model membranes and computational recognition analysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Membrane interaction is not evidence that choline intake increases silica injury or protects against it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The phosphocholine headgroup creates a molecular link to membrane composition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Molecular recognition between membrane epitopes and nearly free surface silanols explains silica membranolytic activity. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35738078/ · DOI 10.1016/j.colsurfb.2022.112625","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5df8963d-63a2-5e3e-a2f9-cbb387da21f1","evidence_kind":"source_excerpt","locator":"Lines 400-406","start_line":400,"end_line":406,"excerpt":"## silica-phosphocholine-recognition\nThe phosphocholine headgroup creates a molecular link to membrane composition.\nNFS-rich silica strongly adsorbed zwitterionic phospholipid assemblies and disrupted their order more than negatively charged liposomes.\nModel: Model membranes and computational recognition analysis.\nLimitations: Membrane interaction is not evidence that choline intake increases silica injury or protects against it.\nEvidence access: Primary full text\nMolecular recognition between membrane epitopes and nearly free surface silanols explains silica membranolytic activity. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35738078/ · DOI 10.1016/j.colsurfb.2022.112625","model_system":"Model membranes and computational recognition analysis.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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