{"id":"aed2d2d7-448b-5541-beea-9c64be7588f5","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-pisd-lipid-rescue","predicate":"restores","statement":"Lyso-PE treatment and genetic complementation restored mitochondrial and lysosomal morphology in PISD patient fibroblasts.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9447b92d-9659-5bad-bdd4-67e2ef2838f1","mechanism_event_label":"Supplying a downstream lipid can bypass a specific defect in culture.","subject":{"id":"dfd7a992-ce6a-519f-9354-35f278182709","slug":"lysophosphatidylethanolamine","display_name":"Lysophosphatidylethanolamine","entity_type_key":"lipid"},"object":{"id":"63e01a6b-f4f4-5c49-b870-87aa9032799e","slug":"human-pisd-patient-organelle-morphology","display_name":"Organelle morphology in PISD patient fibroblasts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9447b92d-9659-5bad-bdd4-67e2ef2838f1","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-pisd-lipid-rescue-event","event_type":"observed_relationship","label":"Supplying a downstream lipid can bypass a specific defect in culture.","description":"Lyso-PE treatment and genetic complementation restored mitochondrial and lysosomal morphology in PISD patient fibroblasts.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dfd7a992-ce6a-519f-9354-35f278182709","slug":"lysophosphatidylethanolamine","display_name":"Lysophosphatidylethanolamine","entity_type_key":"lipid"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"63e01a6b-f4f4-5c49-b870-87aa9032799e","slug":"human-pisd-patient-organelle-morphology","display_name":"Organelle morphology in PISD patient fibroblasts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"43fe17a3-6659-5d31-9be7-959e6bb3f50f","slug":"pisd","display_name":"Human phosphatidylserine decarboxylase / PISD","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"be4a52f4-f31c-59b7-b0da-4178fbb069c8","slug":"phosphatidylethanolamine","display_name":"Phosphatidylethanolamine","entity_type_key":"lipid"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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