{"id":"aed0b6cb-75de-5836-851c-3e9c9f22ede9","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-infant-acute-cardiomyopathy","predicate":"severe-deficiency-associated-with","statement":"In the 11-child severe-case series, three of five children with cardiac involvement had cardiomyopathy and died during the acute phase.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"f0dacc96-6bd4-548c-8fd4-f780685ba0da","mechanism_event_label":"Severe infant thiamine deficiency could involve fatal heart disease.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"2ab3a89c-b2e2-5c94-96e3-58c08e640e71","slug":"infant-cardiomyopathy","display_name":"Infant cardiomyopathy","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f0dacc96-6bd4-548c-8fd4-f780685ba0da","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-infant-acute-cardiomyopathy-event","event_type":"observed_intervention","label":"Severe infant thiamine deficiency could involve fatal heart disease.","description":"In the 11-child severe-case series, three of five children with cardiac involvement had cardiomyopathy and died during the acute phase.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2ab3a89c-b2e2-5c94-96e3-58c08e640e71","slug":"infant-cardiomyopathy","display_name":"Infant cardiomyopathy","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_location","value_text":"Abstract Patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"had cardiomyopathy and died in the acute phase","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Case series of 11 severely affected children from the Israeli thiamine-deficient formula outbreak, with longitudinal follow-up of eight initial survivors.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Consumption of a formula with thiamine below the assay detection limit","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selected severe cases cannot estimate risk among all formula-exposed infants or demonstrate a particular molecular cause of cardiomyopathy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Severe infant thiamine deficiency could involve fatal heart disease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mimouni-bloch-2014-infant-followup] Thiamine deficiency in infancy: long-term follow-up. (2014). https://pubmed.ncbi.nlm.nih.gov/25160536/ DOI: 10.1016/j.pediatrneurol.2014.05.010","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Heart and clinical course","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e4c38579-5f20-5a3e-89f8-96ce755d4b17","evidence_kind":"source_excerpt","locator":"Lines 1507-1519","start_line":1507,"end_line":1519,"excerpt":"### thiamine-def-infant-acute-cardiomyopathy\nIn the 11-child severe-case series, three of five children with cardiac involvement had cardiomyopathy and died during the acute phase.\nCondition category: nutrient_deficiency\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Severe infant thiamine deficiency could involve fatal heart disease.\norganism: Homo sapiens\ntissue_or_cell_type: Heart and clinical course\nexperimental_model: Case series of 11 severely affected children from the Israeli thiamine-deficient formula outbreak, with longitudinal follow-up of eight initial survivors.\nlimitations: Selected severe cases cannot estimate risk among all formula-exposed infants or demonstrate a particular molecular cause of cardiomyopathy.\nevidence_location: Abstract Patients\nevidence_span: had cardiomyopathy and died in the acute phase\nexposure: Consumption of a formula with thiamine below the assay detection limit\n[mimouni-bloch-2014-infant-followup] Thiamine deficiency in infancy: long-term follow-up. 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