{"id":"ae999d8b-d1c5-5293-9462-7fcc86258899","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-crgi-acetate","predicate":"increases","statement":"The carrot RG-I model intervention increased acetate by a reported 21.1 mM.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ea1a5654-5038-5a18-bf63-8cc625e5623b","mechanism_event_label":"This particular extract supported microbial production of acetate in simulated colons.","subject":{"id":"05a9280a-01fb-520f-9be1-aaac56235136","slug":"carrot-rg-i-extract","display_name":"Carrot pectin extract enriched in RG-I","entity_type_key":"chemical_species"},"object":{"id":"e366e758-1fb0-5573-aed1-34f6df874ac7","slug":"acetate","display_name":"Acetate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"ea1a5654-5038-5a18-bf63-8cc625e5623b","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-crgi-acetate-event","event_type":"biochemical_relationship","label":"This particular extract supported microbial production of acetate in simulated colons.","description":"The carrot RG-I model intervention increased acetate by a reported 21.1 mM.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"05a9280a-01fb-520f-9be1-aaac56235136","slug":"carrot-rg-i-extract","display_name":"Carrot pectin extract enriched in RG-I","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e366e758-1fb0-5573-aed1-34f6df874ac7","slug":"acetate","display_name":"Acetate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/34683463.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"38a179d5d001092c0d9595bb3d93ae4fcf8780bb7ae6286e0edfd27971c2aabc\", \"start_char\": 0, \"end_char\": 1830, \"text_sha256\": \"38a179d5d001092c0d9595bb3d93ae4fcf8780bb7ae6286e0edfd27971c2aabc\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"M-SHIME simulated colons with four donor microbiotas","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Carrot RG-I extract, 3 g/day for three weeks in the model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No human host received this regimen in this experiment. 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Donor-specific cultures and product composition limit extrapolation.\nexposure: Carrot RG-I extract, 3 g/day for three weeks in the model\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/34683463.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"38a179d5d001092c0d9595bb3d93ae4fcf8780bb7ae6286e0edfd27971c2aabc\", \"start_char\": 0, \"end_char\": 1830, \"text_sha256\": \"38a179d5d001092c0d9595bb3d93ae4fcf8780bb7ae6286e0edfd27971c2aabc\"}\n[pectin-p34683463] Consistent Prebiotic Effects of Carrot RG-I on the Gut Microbiota of Four Human Adult Donors in the SHIME® Model despite Baseline Individual Variability. 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