{"id":"ae8508cc-c8fc-50b4-8c30-d0e2e9c65453","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-cortisol-null","predicate":"did_not_significantly_change_versus_placebo","statement":"Salivary cortisol changes did not significantly differ between theanine and placebo groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"17d9ad38-285b-527b-bc5c-f1cfa40f796b","mechanism_event_label":"The biochemical stress marker did not establish a treatment advantage.","subject":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"object":{"id":"355b6ffb-4dbc-5bd1-9ac5-013e73d50829","slug":"salivary-cortisol-change","display_name":"Salivary cortisol change","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"17d9ad38-285b-527b-bc5c-f1cfa40f796b","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-cortisol-null-event","event_type":"observed_intervention","label":"The biochemical stress marker did not establish a treatment advantage.","description":"Salivary cortisol changes did not significantly differ between theanine and placebo groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"355b6ffb-4dbc-5bd1-9ac5-013e73d50829","slug":"salivary-cortisol-change","display_name":"Salivary cortisol change","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/38758503.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"aebe7d7493418c65df97e44dd0e07e73f806204c025277f339e4fa99048d13cc\", \"start_char\": 0, \"end_char\": 2433, \"text_sha256\": \"aebe7d7493418c65df97e44dd0e07e73f806204c025277f339e4fa99048d13cc\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"400 mg/day for 28 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small sample and several endpoints. Similar within-group stress reductions are not evidence of placebo-controlled superiority; less sleep is not inherently a benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"30 healthy adults; 15 per group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The biochemical stress marker did not establish a treatment advantage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p38758503] Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial. (2024). https://pubmed.ncbi.nlm.nih.gov/38758503/ DOI: 10.1007/s40120-024-00624-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Stress, salivary cortisol and sleep","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2be82eac-4b01-5e8a-b074-35b2665e4dba","evidence_kind":"source_excerpt","locator":"Lines 1199-1210","start_line":1199,"end_line":1210,"excerpt":"### theanine-cortisol-null\nSalivary cortisol changes did not significantly differ between theanine and placebo groups.\nCondition category: normal\nnutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The biochemical stress marker did not establish a treatment advantage.\norganism: 30 healthy adults; 15 per group\ntissue_or_cell_type: Stress, salivary cortisol and sleep\nexperimental_model: Randomized double-blind placebo-controlled trial\nlimitations: Small sample and several endpoints. Similar within-group stress reductions are not evidence of placebo-controlled superiority; less sleep is not inherently a benefit.\nexposure: 400 mg/day for 28 days\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/38758503.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"aebe7d7493418c65df97e44dd0e07e73f806204c025277f339e4fa99048d13cc\", \"start_char\": 0, \"end_char\": 2433, \"text_sha256\": \"aebe7d7493418c65df97e44dd0e07e73f806204c025277f339e4fa99048d13cc\"}\n[theanine-p38758503] Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial. 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