{"id":"ae4085f2-1ac8-5e9e-972f-33ca7b941df0","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-trpv1","predicate":"activates","statement":"Adding 6-gingerol activated mouse TRPV1 channels in electrophysiological experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"2472d976-5776-54ef-bc7b-0dfee3370f27","mechanism_event_label":"Adding 6-gingerol activated mouse TRPV1 channels in electrophysiological experiments.","subject":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"5fb8c3cd-578c-568e-a1f8-bbd7191968c4","slug":"mouse-trpv1","display_name":"Mouse transient receptor potential vanilloid 1 / Trpv1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"2472d976-5776-54ef-bc7b-0dfee3370f27","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-trpv1-event","event_type":"observed_relationship","label":"Adding 6-gingerol activated mouse TRPV1 channels in electrophysiological experiments.","description":"Adding 6-gingerol activated mouse TRPV1 channels in electrophysiological experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5fb8c3cd-578c-568e-a1f8-bbd7191968c4","slug":"mouse-trpv1","display_name":"Mouse transient receptor potential vanilloid 1 / Trpv1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"6-Gingerol concentration-response; reported EC50 2.9 +/- 0.3 micromolar","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute electrophysiological recordings","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract. Publisher/PMC results inspected for channel species and concentration-response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse TRPV1 expressed in a heterologous-cell system","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mouse channel data; docking and mutagenesis do not constitute a solved gingerol-bound structure or clinical analgesic efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mouse TRPV1 expressed in a heterologous-cell system","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding 6-gingerol activated mouse TRPV1 channels in electrophysiological experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers. (2019). https://pubmed.ncbi.nlm.nih.gov/31207668/ DOI: 10.1111/bph.14766","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro application","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Membrane ion channels","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"71beb021-1770-505b-9b16-4780a4699d24","evidence_kind":"source_excerpt","locator":"Lines 41-50","start_line":41,"end_line":50,"excerpt":"## gingerols-6-trpv1\nAdding 6-gingerol activated mouse TRPV1 channels in electrophysiological experiments.\nModel/species: Mouse TRPV1 expressed in a heterologous-cell system\nTissue: Membrane ion channels\nExposure: 6-Gingerol concentration-response; reported EC50 2.9 +/- 0.3 micromolar\nRoute: In vitro application\nDuration: Acute electrophysiological recordings\nLimits: Mouse channel data; docking and mutagenesis do not constitute a solved gingerol-bound structure or clinical analgesic efficacy.\nPrimary reference: Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers. (2019). https://pubmed.ncbi.nlm.nih.gov/31207668/ DOI: 10.1111/bph.14766\nAccess: Primary PubMed abstract. Publisher/PMC results inspected for channel species and concentration-response.","model_system":"Mouse TRPV1 expressed in a heterologous-cell system","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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