{"id":"ae1ad98a-09be-59da-8e10-b0e9daf64080","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-skin-pilot","predicate":"improves_tested","statement":"A 24-adult randomized blinded crossover pilot reported lower SCORAD and POEM after four weeks of 4 g/day oral histidine, with no corresponding improvement on placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1c0ffaa1-675f-5fdc-8a81-6bbb824bb203","mechanism_event_label":"A small human study reported symptom-score improvement.","subject":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"object":{"id":"9b332da9-3356-52e6-8605-94f2e8ddd335","slug":"human-histidine-ad-pilot","display_name":"Atopic-dermatitis scores in the histidine pilot","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1c0ffaa1-675f-5fdc-8a81-6bbb824bb203","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-skin-pilot-event","event_type":"observed_relationship","label":"A small human study reported symptom-score improvement.","description":"A 24-adult randomized blinded crossover pilot reported lower SCORAD and POEM after four weeks of 4 g/day oral histidine, with no corresponding improvement on placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9b332da9-3356-52e6-8605-94f2e8ddd335","slug":"human-histidine-ad-pilot","display_name":"Atopic-dermatitis scores in the histidine pilot","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Adult atopic-dermatitis pilot; 4 g histidine or erythritol daily, crossover after eight weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small pilot, carryover and generalizability limitations; patent/company interest disclosed. The culture mechanism was not proven to mediate the clinical change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A small human study reported symptom-score improvement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29042806/ · DOI 10.2147/CCID.S146760","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"58860493-a413-51d3-b6a8-69c7bb2fb376","evidence_kind":"source_excerpt","locator":"Lines 426-432","start_line":426,"end_line":432,"excerpt":"## histidine-skin-pilot\nA small human study reported symptom-score improvement.\nA 24-adult randomized blinded crossover pilot reported lower SCORAD and POEM after four weeks of 4 g/day oral histidine, with no corresponding improvement on placebo.\nModel: Adult atopic-dermatitis pilot; 4 g histidine or erythritol daily, crossover after eight weeks.\nLimitations: Small pilot, carryover and generalizability limitations; patent/company interest disclosed. The culture mechanism was not proven to mediate the clinical change.\nEvidence access: Primary full text\nFeeding filaggrin: effects of l-histidine supplementation in atopic dermatitis. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29042806/ · DOI 10.2147/CCID.S146760","model_system":"Adult atopic-dermatitis pilot; 4 g histidine or erythritol daily, crossover after eight weeks.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ce59e6c9-1213-523b-9d0b-400b7a81cd1c","stable_key":"import-911fb3c7-8cc3-5667-b677-5682fab67648","title":"L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"cb672530ec8b4a4542d0f3957e80ca76bb0449e9f988845b0f7681f623c4ec9b","revision_id":"19a7f26c-d9a1-5411-a81d-025f3d98a452","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}