{"id":"adea61e6-05f9-5b31-9c25-e85978df7406","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-regional-subclinical","predicate":"higher-regional-exposure-associated-with","statement":"Five-year subclinical hypothyroidism incidence was 0.2%, 2.6% and 2.9% in the regions with mildly deficient, more-than-adequate and excessive iodine exposure, respectively.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5cde489e-43e9-582b-ba79-d5d7134c9958","mechanism_event_label":"Higher regional iodine exposure was associated with more subclinical hypothyroidism.","subject":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"object":{"id":"6d209165-c8ff-5378-8645-94d1ccc0fbaf","slug":"subclinical-hypothyroidism-incidence","display_name":"Subclinical hypothyroidism incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5cde489e-43e9-582b-ba79-d5d7134c9958","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-regional-subclinical-event","event_type":"observed_intervention","label":"Higher regional iodine exposure was associated with more subclinical hypothyroidism.","description":"Five-year subclinical hypothyroidism incidence was 0.2%, 2.6% and 2.9% in the regions with mildly deficient, more-than-adequate and excessive iodine exposure, respectively.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"240520a5-5777-5f4f-aa45-1dfca6abc55d","slug":"urinary-iodine-concentration","display_name":"Urinary iodine concentration","entity_type_key":"cellular_process"},"role":"regional exposure proxy","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6d209165-c8ff-5378-8645-94d1ccc0fbaf","slug":"subclinical-hypothyroidism-incidence","display_name":"Subclinical hypothyroidism incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective five-year observational follow-up in three Chinese regions;3761 enrolled and 3018 followed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Regional baseline median urinary iodine 84, 243 and 651 micrograms/L; followed 1999–2004.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Regional exposure is not randomized individual dosing; confounding and baseline susceptibility may contribute. Median urinary iodine defines cohort exposure, not an individual disease threshold. The corresponding overt hypothyroidism incidences were 0.2%, 0.5% and 0.3%, so the study does not show a monotonic rise for every thyroid outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Higher regional iodine exposure was associated with more subclinical hypothyroidism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-teng2006] Effect of iodine intake on thyroid diseases in China. (2006). https://pubmed.ncbi.nlm.nih.gov/16807415/ DOI: 10.1056/nejmoa054022","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum thyroid function/antibodies and thyroid ultrasound","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"87edb165-2296-599b-911e-ce24ac621b5f","evidence_kind":"source_excerpt","locator":"Lines 1482-1494","start_line":1482,"end_line":1494,"excerpt":"### iod-clin-regional-subclinical\nFive-year subclinical hypothyroidism incidence was 0.2%, 2.6% and 2.9% in the regions with mildly deficient, more-than-adequate and excessive iodine exposure, respectively.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Higher regional iodine exposure was associated with more subclinical hypothyroidism.\norganism: Homo sapiens\ntissue_or_cell_type: Serum thyroid function/antibodies and thyroid ultrasound\nexperimental_model: Prospective five-year observational follow-up in three Chinese regions;3761 enrolled and 3018 followed\nlimitations: Regional exposure is not randomized individual dosing; confounding and baseline susceptibility may contribute. Median urinary iodine defines cohort exposure, not an individual disease threshold. The corresponding overt hypothyroidism incidences were 0.2%, 0.5% and 0.3%, so the study does not show a monotonic rise for every thyroid outcome.\nexposure: Regional baseline median urinary iodine 84, 243 and 651 micrograms/L; followed 1999–2004.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[iod-clin-teng2006] Effect of iodine intake on thyroid diseases in China. (2006). https://pubmed.ncbi.nlm.nih.gov/16807415/ DOI: 10.1056/nejmoa054022","model_system":"Prospective five-year observational follow-up in three Chinese regions;3761 enrolled and 3018 followed","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-teng2006] Effect of iodine intake on thyroid diseases in China. (2006). https://pubmed.ncbi.nlm.nih.gov/16807415/ DOI: 10.1056/nejmoa054022","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a4885eb6f58bad4a4514c958b63834619e57b10aa7f694aa97d0f65c7d36548f","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}