{"id":"ade2a0f6-edac-5f74-a4f5-750bb6cb1884","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-fasting-hcy","predicate":"modestly_increases","statement":"At 20 hours, fasting total homocysteine was 4% higher, a 0.4 micromol/L difference (95% CI 0.0-0.8).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cd83097b-f6a1-5970-aa6d-b94d4095c592","mechanism_event_label":"Timing changed the size and precision of the measured effect.","subject":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"object":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"cd83097b-f6a1-5970-aa6d-b94d4095c592","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-fasting-hcy-event","event_type":"observed_intervention","label":"Timing changed the size and precision of the measured effect.","description":"At 20 hours, fasting total homocysteine was 4% higher, a 0.4 micromol/L difference (95% CI 0.0-0.8).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/11237928.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b141ca7b40578ff2c375240255347999acc1d82cf721d117c96ff1a057d667e2\", \"start_char\": 0, \"end_char\": 1765, \"text_sha256\": \"b141ca7b40578ff2c375240255347999acc1d82cf721d117c96ff1a057d667e2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized-order four-period crossover in 20 adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2 g/day CGA for 7 days versus placebo; black tea and rutin comparator periods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High supplemental exposure. 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(2001). https://pubmed.ncbi.nlm.nih.gov/11237928/ DOI: 10.1093/ajcn/73.3.532","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma total homocysteine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6f0ad178-e6af-54c5-89a1-1c2772af3588","evidence_kind":"source_excerpt","locator":"Lines 880-891","start_line":880,"end_line":891,"excerpt":"### chlorogenic_acid-fasting-hcy\nAt 20 hours, fasting total homocysteine was 4% higher, a 0.4 micromol/L difference (95% CI 0.0-0.8).\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Timing changed the size and precision of the measured effect.\norganism: Human\ntissue_or_cell_type: Plasma total homocysteine\nexperimental_model: Randomized-order four-period crossover in 20 adults\nlimitations: High supplemental exposure. Homocysteine is a biomarker; this study did not establish cardiovascular harm, depletion of folate/B12/B6, or failure of the methylation cycle.\nexposure: 2 g/day CGA for 7 days versus placebo; black tea and rutin comparator periods\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/11237928.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b141ca7b40578ff2c375240255347999acc1d82cf721d117c96ff1a057d667e2\", \"start_char\": 0, \"end_char\": 1765, \"text_sha256\": \"b141ca7b40578ff2c375240255347999acc1d82cf721d117c96ff1a057d667e2\"}\n[chlorogenic_acid-p11237928] Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. 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