{"id":"adb1e39b-cfbe-52f6-8a0c-bc28af14a543","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-muscle-calcium-sensitivity","predicate":"modulates","statement":"Taurine slightly increased contractile calcium sensitivity in human type I fibers, but not type II fibers; maximum calcium-activated force was unchanged in both.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"62f9739b-67ba-5eba-915f-b2b5745177ab","mechanism_event_label":"The contractile response differed between muscle fiber types.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"e12a13e8-c381-5723-ad4b-a6d3b994b776","slug":"human-muscle-calcium-sensitivity","display_name":"Human muscle-fiber contractile calcium sensitivity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"62f9739b-67ba-5eba-915f-b2b5745177ab","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-muscle-calcium-sensitivity-event","event_type":"observed_relationship","label":"The contractile response differed between muscle fiber types.","description":"Taurine slightly increased contractile calcium sensitivity in human type I fibers, but not type II fibers; maximum calcium-activated force was unchanged in both.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e12a13e8-c381-5723-ad4b-a6d3b994b776","slug":"human-muscle-calcium-sensitivity","display_name":"Human muscle-fiber contractile calcium sensitivity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same human skinned-fiber study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small preparation-specific effect; do not merge with rodent muscle or whole-person strength.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The contractile response differed between muscle fiber types.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Acute effects of taurine on sarcoplasmic reticulum Ca2+ accumulation and contractility in human type I and type II skeletal muscle fibers. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25123198/ · DOI 10.1152/japplphysiol.00494.2014","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"758346f0-2191-5018-b28e-b11af7647123","evidence_kind":"source_excerpt","locator":"Lines 457-463","start_line":457,"end_line":463,"excerpt":"## taurine-muscle-calcium-sensitivity\nThe contractile response differed between muscle fiber types.\nTaurine slightly increased contractile calcium sensitivity in human type I fibers, but not type II fibers; maximum calcium-activated force was unchanged in both.\nModel: Same human skinned-fiber study.\nLimitations: Small preparation-specific effect; do not merge with rodent muscle or whole-person strength.\nEvidence access: Primary abstract\nAcute effects of taurine on sarcoplasmic reticulum Ca2+ accumulation and contractility in human type I and type II skeletal muscle fibers. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25123198/ · DOI 10.1152/japplphysiol.00494.2014","model_system":"Same human skinned-fiber study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}