{"id":"ad7a17ba-a507-50d1-992e-b8791cbd23af","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:copper-insufficiency-lox","predicate":"availability_limits","statement":"Dietary copper availability altered tendon lysyl-oxidase activation in the chick experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a1ec5c18-5c10-513a-8a27-c18630df3355","mechanism_event_label":"Insufficient copper can limit a lysine-processing enzyme even when its substrate is present.","subject":{"id":"2a870bb5-05a0-5e51-a70c-a9a843a8b571","slug":"copper-ii","display_name":"Copper(II) ion","entity_type_key":"ion"},"object":{"id":"a10a83c3-9021-5768-857c-bc976a73aa9a","slug":"lox-activity","display_name":"Lysyl oxidase catalytic activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a1ec5c18-5c10-513a-8a27-c18630df3355","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:copper-insufficiency-lox-event","event_type":"biochemical_relationship","label":"Insufficient copper can limit a lysine-processing enzyme even when its substrate is present.","description":"Dietary copper availability altered tendon lysyl-oxidase activation in the chick experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2a870bb5-05a0-5e51-a70c-a9a843a8b571","slug":"copper-ii","display_name":"Copper(II) ion","entity_type_key":"ion"},"role":"input","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a10a83c3-9021-5768-857c-bc976a73aa9a","slug":"lox-activity","display_name":"Lysyl oxidase catalytic activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"43675a5c-ac37-5f23-9467-60999708a539","slug":"lox","display_name":"LOX","entity_type_key":"protein"},"role":"enzyme","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Chicks receiving diets differing in copper; tendon enzyme assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Copper manipulation in chicks, not evidence of dietary lysine deficiency or a human copper/lysine dose recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Chicken","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Insufficient copper can limit a lysine-processing enzyme even when its substrate is present.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lox-copper-1999] Activation of chick tendon lysyl oxidase in response to dietary copper (1999). https://pubmed.ncbi.nlm.nih.gov/10573541/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Tendon","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"512c0d51-949f-56f5-8198-01e1ee635211","evidence_kind":"source_excerpt","locator":"Lines 497-505","start_line":497,"end_line":505,"excerpt":"### copper-insufficiency-lox\nDietary copper availability altered tendon lysyl-oxidase activation in the chick experiments.\nPlain language: Insufficient copper can limit a lysine-processing enzyme even when its substrate is present.\nCondition category: nutrient_deficiency\norganism: Chicken\ntissue_or_cell_type: Tendon\nexperimental_model: Chicks receiving diets differing in copper; tendon enzyme assays.\nlimitations: Copper manipulation in chicks, not evidence of dietary lysine deficiency or a human copper/lysine dose recommendation.\n[lox-copper-1999] Activation of chick tendon lysyl oxidase in response to dietary copper (1999). https://pubmed.ncbi.nlm.nih.gov/10573541/","model_system":"Chicks receiving diets differing in copper; tendon enzyme assays.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [lox-copper-1999] Activation of chick tendon lysyl oxidase in response to dietary copper (1999). https://pubmed.ncbi.nlm.nih.gov/10573541/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}