{"id":"ad75aec1-5af4-54d3-bb96-32fc4b17aa7b","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-free-exposure","predicate":"yields_low_concentration","statement":"After the 25 mg oral dose in six volunteers, unchanged resveratrol in plasma was below 5 ng/mL despite substantial absorption.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b56efe7c-b2ed-535c-8e5d-b2292cb9e6a6","mechanism_event_label":"Rapid metabolism limits circulating parent compound.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"16e665fe-8fd9-5900-b7fa-dacad0dc1608","slug":"human-plasma-unconjugated-resveratrol","display_name":"Human plasma unconjugated resveratrol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b56efe7c-b2ed-535c-8e5d-b2292cb9e6a6","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-free-exposure-event","event_type":"observed_relationship","label":"Rapid metabolism limits circulating parent compound.","description":"After the 25 mg oral dose in six volunteers, unchanged resveratrol in plasma was below 5 ng/mL despite substantial absorption.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"16e665fe-8fd9-5900-b7fa-dacad0dc1608","slug":"human-plasma-unconjugated-resveratrol","display_name":"Human plasma unconjugated resveratrol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human radiotracer study; single dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a universal exposure ceiling across formulations or doses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Rapid metabolism limits circulating parent compound.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"High absorption but very low bioavailability of oral resveratrol in humans. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15333514/ · DOI 10.1124/dmd.104.000885","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"200a6844-a9cc-58d2-9e7a-7ca418922a18","evidence_kind":"source_excerpt","locator":"Lines 22-28","start_line":22,"end_line":28,"excerpt":"## resveratrol-human-free-exposure\nRapid metabolism limits circulating parent compound.\nAfter the 25 mg oral dose in six volunteers, unchanged resveratrol in plasma was below 5 ng/mL despite substantial absorption.\nModel: Human radiotracer study; single dose.\nLimitations: Not a universal exposure ceiling across formulations or doses.\nEvidence access: Primary abstract\nHigh absorption but very low bioavailability of oral resveratrol in humans. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15333514/ · DOI 10.1124/dmd.104.000885","model_system":"Human radiotracer study; single dose.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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