{"id":"ad3ad6a6-503a-52ee-a610-00ff5e9a8b0d","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ver-alpha-t3-liposomal-oxidation","predicate":"inhibits","statement":"Alpha-tocotrienol suppressed AAPH-initiated liposomal oxidation more strongly than alpha-tocopherol in the study’s FENIX assay, which tracked competitive oxidation of a fluorescent reporter.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"de4922b9-8e5f-529e-8e32-a6b711beaf27","mechanism_event_label":"The two alpha forms differed in protection of artificial lipid membranes.","subject":{"id":"45597684-ead7-5ebe-975a-ac3bc714e22c","slug":"alpha-tocotrienol","display_name":"Alpha-tocotrienol","entity_type_key":"small_molecule"},"object":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"de4922b9-8e5f-529e-8e32-a6b711beaf27","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ver-alpha-t3-liposomal-oxidation-event","event_type":"biochemical_relationship","label":"The two alpha forms differed in protection of artificial lipid membranes.","description":"Alpha-tocotrienol suppressed AAPH-initiated liposomal oxidation more strongly than alpha-tocopherol in the study’s FENIX assay, which tracked competitive oxidation of a fluorescent reporter.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"45597684-ead7-5ebe-975a-ac3bc714e22c","slug":"alpha-tocotrienol","display_name":"Alpha-tocotrienol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Figure 4A; FENIX Methods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free fluorescence-enabled inhibited autoxidation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Vitamin E forms tested at 1, 10 and 100 µM; 1 mM lipid, 1 mM AAPH, 37 °C.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Potency in cell assays does not establish nutritional equivalence or human efficacy; the study also detected toxicity at higher concentrations, with tocotrienols toxic at lower concentrations than tocopherols. Fluorescent reporter kinetics are not a universal radical-trapping rate constant.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Cell-free","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The two alpha forms differed in protection of artificial lipid membranes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ver-yang2026] Tocotrienols exhibit superior ferroptosis inhibition over tocopherols. (2026). https://pubmed.ncbi.nlm.nih.gov/41501350/ DOI: 10.1038/s41598-025-34673-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Phosphatidylcholine liposomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"877f6064-a5d7-5e4c-a5e0-7faf93985cd8","evidence_kind":"source_excerpt","locator":"Lines 788-800","start_line":788,"end_line":800,"excerpt":"### ver-alpha-t3-liposomal-oxidation\nAlpha-tocotrienol suppressed AAPH-initiated liposomal oxidation more strongly than alpha-tocopherol in the study’s FENIX assay, which tracked competitive oxidation of a fluorescent reporter.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The two alpha forms differed in protection of artificial lipid membranes.\norganism: Cell-free\ntissue_or_cell_type: Phosphatidylcholine liposomes\nexperimental_model: Cell-free fluorescence-enabled inhibited autoxidation\nlimitations: Potency in cell assays does not establish nutritional equivalence or human efficacy; the study also detected toxicity at higher concentrations, with tocotrienols toxic at lower concentrations than tocopherols. Fluorescent reporter kinetics are not a universal radical-trapping rate constant.\nexposure: Vitamin E forms tested at 1, 10 and 100 µM; 1 mM lipid, 1 mM AAPH, 37 °C.\ncross_nutrient: false\nevidence_location: Figure 4A; FENIX Methods\n[ver-yang2026] Tocotrienols exhibit superior ferroptosis inhibition over tocopherols. (2026). https://pubmed.ncbi.nlm.nih.gov/41501350/ DOI: 10.1038/s41598-025-34673-1","model_system":"Cell-free fluorescence-enabled inhibited autoxidation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ver-yang2026] Tocotrienols exhibit superior ferroptosis inhibition over tocopherols. 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