{"id":"ad12f306-41c3-5b76-908c-d46e06f62c87","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-egg-matrix","predicate":"increases","statement":"The high-egg salad meal increased lutein/zeaxanthin lipoprotein AUC about four- to fivefold versus salad without egg.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"11c0c4e0-2f8b-545d-823f-2e2d56535b80","mechanism_event_label":"The whole-food meal increased carotenoid appearance in blood.","subject":{"id":"7bae42e0-b693-55d6-8c5d-8a2da34df266","slug":"human-salad-whole-egg-meal","display_name":"Salad plus 150 g scrambled whole eggs in the 2015 crossover study","entity_type_key":"chemical_species"},"object":{"id":"2d2c44d2-90fa-5efd-aef6-7c326ca09926","slug":"postmeal-lutein-response","display_name":"Human post-meal plasma lutein response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"11c0c4e0-2f8b-545d-823f-2e2d56535b80","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-egg-matrix-event","event_type":"observed_intervention","label":"The whole-food meal increased carotenoid appearance in blood.","description":"The high-egg salad meal increased lutein/zeaxanthin lipoprotein AUC about four- to fivefold versus salad without egg.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"role":"measured_carotenoid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0a60c685-7502-5ece-9da2-2c1a2e3bcdf1","slug":"zeaxanthin","display_name":"Dietary (3R,3-prime-R)-zeaxanthin","entity_type_key":"small_molecule"},"role":"co_measured_carotenoid","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7bae42e0-b693-55d6-8c5d-8a2da34df266","slug":"human-salad-whole-egg-meal","display_name":"Salad plus 150 g scrambled whole eggs in the 2015 crossover study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2d2c44d2-90fa-5efd-aef6-7c326ca09926","slug":"postmeal-lutein-response","display_name":"Human post-meal plasma lutein response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/26016861.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c275d8263df6d127f722fc47b45e9bc513c6d871653afbc878bc50a911b1df55\", \"start_char\": 0, \"end_char\": 2045, \"text_sha256\": \"c275d8263df6d127f722fc47b45e9bc513c6d871653afbc878bc50a911b1df55\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized three-meal crossover trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Salad plus 0, 75 or 150 g scrambled whole eggs; ten-hour sampling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Eggs supplied both fat and carotenoids; the experiment does not isolate a choline effect. Published erratum 10.3945/ajcn.115.120956 corrects an author affiliation to Department of Nutrition Science; it does not change the trial outcomes. Correction: https://doi.org/10.3945/ajcn.115.120956 .","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"16 healthy young men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The whole-food meal increased carotenoid appearance in blood.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p26016861] Effects of egg consumption on carotenoid absorption from co-consumed, raw vegetables. (2015). https://pubmed.ncbi.nlm.nih.gov/26016861/ DOI: 10.3945/ajcn.115.111062","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Post-meal triglyceride-rich lipoproteins","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"70a5a7bd-9fab-54ef-8af3-3049a50c6060","evidence_kind":"source_excerpt","locator":"Lines 593-604","start_line":593,"end_line":604,"excerpt":"### lutein-egg-matrix\nThe high-egg salad meal increased lutein/zeaxanthin lipoprotein AUC about four- to fivefold versus salad without egg.\nCondition category: normal\nnutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The whole-food meal increased carotenoid appearance in blood.\norganism: 16 healthy young men\ntissue_or_cell_type: Post-meal triglyceride-rich lipoproteins\nexperimental_model: Randomized three-meal crossover trial\nlimitations: Eggs supplied both fat and carotenoids; the experiment does not isolate a choline effect. Published erratum 10.3945/ajcn.115.120956 corrects an author affiliation to Department of Nutrition Science; it does not change the trial outcomes. Correction: https://doi.org/10.3945/ajcn.115.120956 .\nexposure: Salad plus 0, 75 or 150 g scrambled whole eggs; ten-hour sampling\nevidence_span: {\"source_cache\": \"artifacts/lutein-research/26016861.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c275d8263df6d127f722fc47b45e9bc513c6d871653afbc878bc50a911b1df55\", \"start_char\": 0, \"end_char\": 2045, \"text_sha256\": \"c275d8263df6d127f722fc47b45e9bc513c6d871653afbc878bc50a911b1df55\"}\n[lutein-p26016861] Effects of egg consumption on carotenoid absorption from co-consumed, raw vegetables. (2015). https://pubmed.ncbi.nlm.nih.gov/26016861/ DOI: 10.3945/ajcn.115.111062","model_system":"Randomized three-meal crossover trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lutein-p26016861] Effects of egg consumption on carotenoid absorption from co-consumed, raw vegetables. (2015). https://pubmed.ncbi.nlm.nih.gov/26016861/ DOI: 10.3945/ajcn.115.111062","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"beef4241-6ebd-5b36-864c-6ef3ed7e61b8","stable_key":"import-cfa4bd86-d88d-555a-975c-68877bf00e0f","title":"Lutein: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"1514ec459913a7044b4c4e1012ed367bcb918298181ebabd2a9e2ccecd789053","revision_id":"bae2c856-0785-546f-b08f-869318c27f9e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}