{"id":"ad04edd2-3bdb-5c33-921e-f99e8c042ff5","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-absorption","predicate":"is_absorbed","statement":"In six volunteers given 25 mg radiolabeled oral resveratrol, estimated absorption was at least 70%.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f217761d-4fd0-51e0-9105-088127c18fea","mechanism_event_label":"Absorption does not mean most of the dose circulates unchanged.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"6ed85841-4652-50aa-b054-58267e8accca","slug":"human-oral-resveratrol-absorption","display_name":"Human oral resveratrol absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f217761d-4fd0-51e0-9105-088127c18fea","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-absorption-event","event_type":"observed_relationship","label":"Absorption does not mean most of the dose circulates unchanged.","description":"In six volunteers given 25 mg radiolabeled oral resveratrol, estimated absorption was at least 70%.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6ed85841-4652-50aa-b054-58267e8accca","slug":"human-oral-resveratrol-absorption","display_name":"Human oral resveratrol absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"61e08499-3296-56f9-9656-e7263b876637","slug":"trans-resveratrol","display_name":"trans-Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human oral/IV radiotracer study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The approximately 2 micromolar peak represented parent plus metabolites, not free resveratrol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Absorption does not mean most of the dose circulates unchanged.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"High absorption but very low bioavailability of oral resveratrol in humans. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15333514/ · DOI 10.1124/dmd.104.000885","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6f9ea448-9e7d-57d1-8f16-62ab64625258","evidence_kind":"source_excerpt","locator":"Lines 14-20","start_line":14,"end_line":20,"excerpt":"## resveratrol-human-absorption\nAbsorption does not mean most of the dose circulates unchanged.\nIn six volunteers given 25 mg radiolabeled oral resveratrol, estimated absorption was at least 70%.\nModel: Human oral/IV radiotracer study.\nLimitations: The approximately 2 micromolar peak represented parent plus metabolites, not free resveratrol.\nEvidence access: Primary abstract\nHigh absorption but very low bioavailability of oral resveratrol in humans. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15333514/ · DOI 10.1124/dmd.104.000885","model_system":"Human oral/IV radiotracer study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}