{"id":"acb4c6ac-d7a7-5e06-80fc-d8472f1e7868","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-autophagy-rescue","predicate":"reduces","statement":"Butyrate addition prevented energy-stress-associated autophagy in germ-free mouse colonocytes, with fuel use rather than HDAC inhibition explaining the rescue.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"883d407d-092b-530f-839e-94fa903b962b","mechanism_event_label":"Supplying energy reduced the need for the cell’s recycling response.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"a4d82d57-0bbc-506d-afea-eb552ea07469","slug":"mouse-colonocyte-autophagy","display_name":"Mouse colonocyte autophagy during microbial metabolite depletion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"883d407d-092b-530f-839e-94fa903b962b","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-autophagy-rescue-event","event_type":"observed_relationship","label":"Supplying energy reduced the need for the cell’s recycling response.","description":"Butyrate addition prevented energy-stress-associated autophagy in germ-free mouse colonocytes, with fuel use rather than HDAC inhibition explaining the rescue.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a4d82d57-0bbc-506d-afea-eb552ea07469","slug":"mouse-colonocyte-autophagy","display_name":"Mouse colonocyte autophagy during microbial metabolite depletion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse colonocyte substrate-rescue experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Autophagy is a context-dependent response, not universally harmful.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Supplying energy reduced the need for the cell’s recycling response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21531334/ · DOI 10.1016/j.cmet.2011.02.018","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e19c87bd-a66f-57e1-8bf1-25bcfa2447b8","evidence_kind":"source_excerpt","locator":"Lines 174-180","start_line":174,"end_line":180,"excerpt":"## butyrate-autophagy-rescue\nSupplying energy reduced the need for the cell’s recycling response.\nButyrate addition prevented energy-stress-associated autophagy in germ-free mouse colonocytes, with fuel use rather than HDAC inhibition explaining the rescue.\nModel: Mouse colonocyte substrate-rescue experiments.\nLimitations: Autophagy is a context-dependent response, not universally harmful.\nEvidence access: Primary abstract\nThe microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21531334/ · DOI 10.1016/j.cmet.2011.02.018","model_system":"Mouse colonocyte substrate-rescue experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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