{"id":"ac90dde4-32f5-559b-943c-4a9b70aebc78","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-immune-migration","predicate":"enhances_tested","statement":"Glutamate increased CXCR4-mediated T-cell chemotactic migration toward CXCL12 in the reported experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f24779aa-0411-5514-9df9-8d0326eaf064","mechanism_event_label":"A metabolic signal interacted with a chemokine-guided movement system.","subject":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"object":{"id":"56d4da85-30a6-509a-a356-4771869d330f","slug":"human-t-cell-cxcl12-migration","display_name":"Human T-cell migration toward CXCL12","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f24779aa-0411-5514-9df9-8d0326eaf064","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-immune-migration-event","event_type":"observed_relationship","label":"A metabolic signal interacted with a chemokine-guided movement system.","description":"Glutamate increased CXCR4-mediated T-cell chemotactic migration toward CXCL12 in the reported experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"56d4da85-30a6-509a-a356-4771869d330f","slug":"human-t-cell-cxcl12-migration","display_name":"Human T-cell migration toward CXCL12","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2f1e3a65-a208-5ebe-a0eb-221a260ec5c8","slug":"cxcr4","display_name":"C-X-C chemokine receptor type 4 / CXCR4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4fa83828-df61-5b83-bc33-35d2b25bddad","slug":"cxcl12","display_name":"Stromal cell-derived factor 1 / SDF-1alpha / CXCL12","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"190a9f62-b95f-57c5-900d-ec35e672ed07","slug":"gria3","display_name":"Human AMPA receptor subunit GluA3 / GRIA3","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human T-cell chemotaxis experiments in the receptor study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not establish disease causation or the direction of a clinical immune effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A metabolic signal interacted with a chemokine-guided movement system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12682273/ · DOI 10.4049/jimmunol.170.8.4362","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ca20f611-49d7-5d98-be4c-8a39c7152d1f","evidence_kind":"source_excerpt","locator":"Lines 362-368","start_line":362,"end_line":368,"excerpt":"## glutamate-immune-migration\nA metabolic signal interacted with a chemokine-guided movement system.\nGlutamate increased CXCR4-mediated T-cell chemotactic migration toward CXCL12 in the reported experiments.\nModel: Human T-cell chemotaxis experiments in the receptor study.\nLimitations: This does not establish disease causation or the direction of a clinical immune effect.\nEvidence access: Primary abstract\nHuman T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12682273/ · DOI 10.4049/jimmunol.170.8.4362","model_system":"Human T-cell chemotaxis experiments in the receptor study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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