{"id":"ac347f24-2734-590f-9bc8-e39c1a2a6913","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-olive-oil-disposition","predicate":"is_extensively_conjugated_in","statement":"After 25 mL virgin olive oil, plasma hydroxytyrosol peaked early, free forms were not detected, and about 98% appeared in conjugated forms; estimated half-life was 2.43 hours.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"25e1cf2c-e389-559b-9740-20e3a07c3467","mechanism_event_label":"After 25 mL virgin olive oil, plasma hydroxytyrosol peaked early, free forms were not detected, and about 98% appeared in conjugated forms; estimated half-life was 2.43 hours.","subject":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"object":{"id":"199faa7b-e4e0-52e7-85f4-c2d991b00db2","slug":"human-hydroxytyrosol-conjugate-pool","display_name":"Human hydroxytyrosol conjugate pool","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"25e1cf2c-e389-559b-9740-20e3a07c3467","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-olive-oil-disposition-event","event_type":"observed_relationship","label":"After 25 mL virgin olive oil, plasma hydroxytyrosol peaked early, free forms were not detected, and about 98% appeared in conjugated forms; estimated half-life was 2.43 hours.","description":"After 25 mL virgin olive oil, plasma hydroxytyrosol peaked early, free forms were not detected, and about 98% appeared in conjugated forms; estimated half-life was 2.43 hours.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"199faa7b-e4e0-52e7-85f4-c2d991b00db2","slug":"human-hydroxytyrosol-conjugate-pool","display_name":"Human hydroxytyrosol conjugate pool","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"25 mL virgin olive oil","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"0-12 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human volunteers after a real-life virgin-olive-oil dose","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Hydrolytic sample preparation estimates conjugated pools; recovery does not prove which conjugate is active.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hydroxytyrosol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human volunteers after a real-life virgin-olive-oil dose","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"After 25 mL virgin olive oil, plasma hydroxytyrosol peaked early, free forms were not detected, and about 98% appeared in conjugated forms; estimated half-life was 2.43 hours.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Hydroxytyrosol disposition in humans. (2003). https://pubmed.ncbi.nlm.nih.gov/12765992/ DOI: 10.1373/49.6.945","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral food","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma and urine hydroxytyrosol and 3-O-methyl-hydroxytyrosol","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"50b9e6a8-b3db-53ed-b3ac-b440baf75654","evidence_kind":"source_excerpt","locator":"Lines 11-20","start_line":11,"end_line":20,"excerpt":"## hydroxytyrosol-olive-oil-disposition\nAfter 25 mL virgin olive oil, plasma hydroxytyrosol peaked early, free forms were not detected, and about 98% appeared in conjugated forms; estimated half-life was 2.43 hours.\nModel/species: Human volunteers after a real-life virgin-olive-oil dose\nTissue/system: Plasma and urine hydroxytyrosol and 3-O-methyl-hydroxytyrosol\nExposure: 25 mL virgin olive oil\nRoute: Oral food\nDuration: 0-12 hours\nLimits: Hydrolytic sample preparation estimates conjugated pools; recovery does not prove which conjugate is active.\nPrimary reference: Hydroxytyrosol disposition in humans. (2003). https://pubmed.ncbi.nlm.nih.gov/12765992/ DOI: 10.1373/49.6.945\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Human volunteers after a real-life virgin-olive-oil dose","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f83cd982-34f0-55d4-8563-eedfb0f009f2","stable_key":"import-cb41aa31-e26b-5b60-b7e0-e4985fb7aea8","title":"Hydroxytyrosol: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"7677fedffc16af238fc1ace3f88d206dd42b29b163c40b6e69ba6ed2457a3aee","revision_id":"1e0bd617-6834-5a2d-a74e-c058967d99b7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}