{"id":"ac33afd6-1d6f-52da-bc71-2a9da88ca1fb","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-parp-depletion-rate","predicate":"inhibition_slows","statement":"The PARP inhibitor Tiq-A slowed early nuclear/cytoplasmic NAD+ depletion after NAMPT inhibition, with little effect on mitochondrial depletion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7e2142ac-0796-58e0-b105-452892af558b","mechanism_event_label":"Consumption can determine how quickly a blocked supply becomes a shortage.","subject":{"id":"d5ab002d-61f0-502f-951a-00b96f059988","slug":"parp1","display_name":"Human PARP1","entity_type_key":"protein"},"object":{"id":"cddc6287-85eb-5b6f-b816-5401e1216000","slug":"human-nucleocytoplasmic-nad-depletion","display_name":"Nucleocytoplasmic NAD depletion during salvage blockade","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7e2142ac-0796-58e0-b105-452892af558b","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-parp-depletion-rate-event","event_type":"observed_relationship","label":"Consumption can determine how quickly a blocked supply becomes a shortage.","description":"The PARP inhibitor Tiq-A slowed early nuclear/cytoplasmic NAD+ depletion after NAMPT inhibition, with little effect on mitochondrial depletion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d5ab002d-61f0-502f-951a-00b96f059988","slug":"parp1","display_name":"Human PARP1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cddc6287-85eb-5b6f-b816-5401e1216000","slug":"human-nucleocytoplasmic-nad-depletion","display_name":"Nucleocytoplasmic NAD depletion during salvage blockade","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8272125c-0d87-5920-9dae-7409b797bbfa","slug":"nampt","display_name":"Human nicotinamide phosphoribosyltransferase / NAMPT","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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