{"id":"ac210c46-c7ae-540b-833b-146b134f8576","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:eight-weeks-of-nsk-sd-lowers-plasma-renin-activity","predicate":"reduces","statement":"The net change in plasma renin activity was -1.17 ng/mL/h against placebo in the same trial.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"fbe2534e-1a56-51c1-ba4a-25f3ca20fb03","mechanism_event_label":"The net change in plasma renin activity was -1.17 ng/mL/h against placebo in the same trial.","subject":{"id":"9910223c-2a27-5d75-8003-91d72e71be9a","slug":"nsk-sd","display_name":"NSK-SD fermented soybean extract","entity_type_key":"chemical_species"},"object":{"id":"df532b38-6c31-5d36-9308-ed4a145b36f1","slug":"plasma-renin-activity","display_name":"Plasma renin activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fbe2534e-1a56-51c1-ba4a-25f3ca20fb03","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:eight-weeks-of-nsk-sd-lowers-plasma-renin-activity-event","event_type":"observed_intervention","label":"The net change in plasma renin activity was -1.17 ng/mL/h against placebo in the same trial.","description":"Plasma","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9910223c-2a27-5d75-8003-91d72e71be9a","slug":"nsk-sd","display_name":"NSK-SD fermented soybean extract","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"df532b38-6c31-5d36-9308-ed4a145b36f1","slug":"plasma-renin-activity","display_name":"Plasma renin activity","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"8 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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Its direction is not reproduced by the North American trial, where an exploratory low-renin subgroup moved the other way.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human (73 completers with elevated blood pressure)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The net change in plasma renin activity was -1.17 ng/mL/h against placebo in the same trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of nattokinase on blood pressure: a randomized, controlled trial. 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