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(1984). https://pubmed.ncbi.nlm.nih.gov/6361565/ DOI: 10.1056/nejm198402023100502","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"2653772d-2dea-5c67-97aa-ac1a7e9b51f6","evidence_kind":"source_excerpt","locator":"Lines 461-472","start_line":461,"end_line":472,"excerpt":"### ibu-kidney-depends-on-what-is-blocked\nIn 10 patients with chronic glomerular disease randomly assigned to one week of ibuprofen, urinary 6-keto-prostaglandin F1 alpha and prostaglandin E2 excretion fell by 80%, serum creatinine rose by 40% and creatinine and para-aminohippurate clearances fell by 28% and 35% respectively, with the reduction in both clearances inversely related to the basal urinary excretion of 6-keto-prostaglandin F1 alpha but not of prostaglandin E2, while no functional changes were detected in five healthy women despite a similar suppression of renal prostacyclin synthesis, and one week of sulindac did not affect renal prostacyclin synthesis or renal function despite marked inhibition of extrarenal cyclooxygenase.\nCondition category: biomarker_context\nnutrient_topic: Ibuprofen research collection; topical membership is not evidence of a direct clinical effect, and the racemate is recorded separately from each of its two enantiomers.\nplain_language: The same drop in kidney prostaglandins does nothing to a healthy kidney and takes a third of the function from a diseased one.\norganism: Human\ntissue_or_cell_type: Kidney\nexperimental_model: Randomised one week treatment in 20 women with chronic glomerular disease and 5 healthy women\nlimitations: The healthy comparison group is what makes this decisive: the same suppression of renal prostacyclin produced no functional change in them. Twenty patients, one week.\nexposure: Ibuprofen for one week, against sulindac in a parallel group\nevidence_span: {\"source_cache\": \"artifacts/ibuprofen-research/6361565.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"98ef6b906f4841d1488baebb3c03c7452c98c5266ae012dd2a0eb579661dc15b\", \"start_char\": 0, \"end_char\": 1550, \"text_sha256\": \"98ef6b906f4841d1488baebb3c03c7452c98c5266ae012dd2a0eb579661dc15b\"}\n[ibu-p6361565] Effects of sulindac and ibuprofen in patients with chronic glomerular disease. Evidence for the dependence of renal function on prostacyclin. (1984). https://pubmed.ncbi.nlm.nih.gov/6361565/ DOI: 10.1056/nejm198402023100502","model_system":"Randomised one week treatment in 20 women with chronic glomerular disease and 5 healthy women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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