{"id":"ab5208b4-a452-5a6f-95a7-99aa72b6544b","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-iron-binding","predicate":"complexes","statement":"Luteolin formed a 1:1 Fe(III) complex in ethanol, with the B-ring catechol assigned as the binding site.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dc325ef0-a364-5902-bb5d-b328b10c85cc","mechanism_event_label":"Iron binding depends on chemical conditions.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"964be7ac-43bd-5f3e-8326-94f0590de67a","slug":"iron-iii","display_name":"Ferric iron","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"dc325ef0-a364-5902-bb5d-b328b10c85cc","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-iron-binding-event","event_type":"observed_relationship","label":"Iron binding depends on chemical conditions.","description":"Luteolin formed a 1:1 Fe(III) complex in ethanol, with the B-ring catechol assigned as the binding site.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"964be7ac-43bd-5f3e-8326-94f0590de67a","slug":"iron-iii","display_name":"Ferric iron","entity_type_key":"ion"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Spectroscopy, mass spectrometry and electrochemistry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Solvent-specific chemistry does not establish intestinal iron depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Iron binding depends on chemical conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Spectroscopic and electrochemical studies on the evaluation of the radical scavenging activities of luteolin by chelating iron · 2014 · https://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra01396d · DOI 10.1039/C4RA01396D","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"17238a3e-c651-5c05-9251-435ed382510d","evidence_kind":"source_excerpt","locator":"Lines 300-306","start_line":300,"end_line":306,"excerpt":"## luteolin-iron-binding\nIron binding depends on chemical conditions.\nLuteolin formed a 1:1 Fe(III) complex in ethanol, with the B-ring catechol assigned as the binding site.\nModel: Spectroscopy, mass spectrometry and electrochemistry.\nLimitations: Solvent-specific chemistry does not establish intestinal iron depletion.\nEvidence access: Primary abstract\nSpectroscopic and electrochemical studies on the evaluation of the radical scavenging activities of luteolin by chelating iron · 2014 · https://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra01396d · DOI 10.1039/C4RA01396D","model_system":"Spectroscopy, mass spectrometry and electrochemistry.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}