{"id":"ab324a02-7b35-55e0-866a-e464de160ed2","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-adenoma-recurrence-null","predicate":"did_not_reduce_adenoma_recurrence","statement":"At the first surveillance interval, adenoma recurrence was 44.1% with folic acid and 42.4% with placebo (RR 1.04; 95% CI 0.90–1.20).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cb8d4880-e6ee-5ed4-b643-12dde00cd072","mechanism_event_label":"The supplement did not prevent recurrent adenomas in this trial.","subject":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"object":{"id":"4c47991c-d43e-542e-b061-839709a6c320","slug":"colorectal-adenoma-recurrence","display_name":"Colorectal adenoma recurrence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cb8d4880-e6ee-5ed4-b643-12dde00cd072","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:fol-adenoma-recurrence-null-event","event_type":"observed_intervention","label":"The supplement did not prevent recurrent adenomas in this trial.","description":"At the first surveillance interval, adenoma recurrence was 44.1% with folic acid and 42.4% with placebo (RR 1.04; 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95% CI 0.90–1.20).\nCondition category: normal\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The supplement did not prevent recurrent adenomas in this trial.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person clinical endpoints\nexperimental_model: Randomized double-blind factorial trial in 1021 adults with recent colorectal adenomas; independently randomized aspirin exposure.\nlimitations: Participants already had adenomas; not a study of ordinary food folate or primary cancer prevention in everyone.\nexposure: Folic acid 1 mg/day versus placebo; colonoscopy at first three-year interval and a later surveillance interval.\n[fol-cole2007] Folic acid for the prevention of colorectal adenomas: a randomized clinical trial (2007). https://pubmed.ncbi.nlm.nih.gov/17551129/ DOI: 10.1001/jama.297.21.2351","model_system":"Randomized double-blind factorial trial in 1021 adults with recent colorectal adenomas; 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Study references: [fol-cole2007] Folic acid for the prevention of colorectal adenomas: a randomized clinical trial (2007). https://pubmed.ncbi.nlm.nih.gov/17551129/ DOI: 10.1001/jama.297.21.2351","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}