{"id":"ab2c2aed-965f-5288-ae3e-d69650728318","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-vegetarian-stores","predicate":"lower_dietary_provision_reduced","statement":"Plasma and muscle creatine declined after adoption of the vegetarian diet; the creatine-plus-beta-alanine group attenuated the decline.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"83445f5b-1d73-5334-9114-d22e510ded7c","mechanism_event_label":"Endogenous production did not fully maintain the previous measured stores in this study.","subject":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"object":{"id":"3967d176-4a04-5f81-b264-b57cd5114890","slug":"muscle-total-creatine","display_name":"Skeletal-muscle total creatine content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"83445f5b-1d73-5334-9114-d22e510ded7c","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-vegetarian-stores-event","event_type":"observed_intervention","label":"Endogenous production did not fully maintain the previous measured stores in this study.","description":"Plasma and muscle creatine declined after adoption of the vegetarian diet; the creatine-plus-beta-alanine group attenuated the decline.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3967d176-4a04-5f81-b264-b57cd5114890","slug":"muscle-total-creatine","display_name":"Skeletal-muscle total creatine content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/29569535.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3f1a5c6540a84e1f679a0b16d2faefd7caa27fac1276ff53744ee25e50e498aa\", \"start_char\": 0, \"end_char\": 1813, \"text_sha256\": \"3f1a5c6540a84e1f679a0b16d2faefd7caa27fac1276ff53744ee25e50e498aa\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six-month dietary intervention with supplement/placebo groups","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Continued omnivorous diet or vegetarian diet with placebo or creatine 1 g/day plus beta-alanine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The schema category nutrient_deficiency describes reduced dietary provision here, not a demonstrated clinical deficiency syndrome. 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Combined supplementation limits causal attribution.\nexposure: Continued omnivorous diet or vegetarian diet with placebo or creatine 1 g/day plus beta-alanine\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/29569535.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3f1a5c6540a84e1f679a0b16d2faefd7caa27fac1276ff53744ee25e50e498aa\", \"start_char\": 0, \"end_char\": 1813, \"text_sha256\": \"3f1a5c6540a84e1f679a0b16d2faefd7caa27fac1276ff53744ee25e50e498aa\"}\n[creatine-p29569535] Changing to a vegetarian diet reduces the body creatine pool in omnivorous women, but appears not to affect carnitine and carnosine homeostasis: a randomised trial. 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