{"id":"ab2b7ef1-90a3-56be-a649-458f9704fa3f","stable_key":"8600a864-6653-52c7-9718-1362c5af4577:gamma-nonalactone-vitamin-e-matrix","predicate":"associated_with_formation_difference","statement":"The lowest-alpha-tocopherol beef-fat group showed the greatest gamma-nonalactone rise during storage: 51.4 ppb, 11.7 times the prestorage level.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"49a24d3f-03c6-583a-a6a7-73cc57aea95a","mechanism_event_label":"The lowest-alpha-tocopherol beef-fat group showed the greatest gamma-nonalactone rise during storage: 51.4 ppb, 11.7 times the prestorage level.","subject":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"object":{"id":"2b85fa4a-5c91-5de9-aead-a443bc4394af","slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"49a24d3f-03c6-583a-a6a7-73cc57aea95a","stable_key":"8600a864-6653-52c7-9718-1362c5af4577:gamma-nonalactone-vitamin-e-matrix-event","event_type":"observed_relationship","label":"The lowest-alpha-tocopherol beef-fat group showed the greatest gamma-nonalactone rise during storage: 51.4 ppb, 11.7 times the prestorage level.","description":"The lowest-alpha-tocopherol beef-fat group showed the greatest gamma-nonalactone rise during storage: 51.4 ppb, 11.7 times the prestorage level.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2b85fa4a-5c91-5de9-aead-a443bc4394af","slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Groups differing in alpha-tocopherol content; lowest 2.9 ppm, highest 28.8 ppm","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"7 days at 2 C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; unresolved method details explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rendered fat from marbled beef; bovine food matrix","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Food oxidation and partitioning are not human nutrient metabolism. The abstract supports a matrix-dependent association, not an intake recommendation or gamma-nonalactone-induced vitamin E depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gamma-nonalactone flavor-compound chapter; nutrient and drug interactions retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rendered fat from marbled beef; bovine food matrix","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The lowest-alpha-tocopherol beef-fat group showed the greatest gamma-nonalactone rise during storage: 51.4 ppb, 11.7 times the prestorage level.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of α-tocopherol on lactone formation in marbled beef and changes in lactone volatility during storage. (2012). https://pubmed.ncbi.nlm.nih.gov/22583190/ DOI: 10.1111/j.1750-3841.2012.02694.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Food-matrix storage; no human administration","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Stored-fat headspace and lactone quantitation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"023c1767-4e9e-5bee-8e22-a03e47961087","evidence_kind":"source_excerpt","locator":"Lines 147-156","start_line":147,"end_line":156,"excerpt":"## gamma-nonalactone-vitamin-e-matrix\nThe lowest-alpha-tocopherol beef-fat group showed the greatest gamma-nonalactone rise during storage: 51.4 ppb, 11.7 times the prestorage level.\nModel/species: Rendered fat from marbled beef; bovine food matrix\nTissue: Stored-fat headspace and lactone quantitation\nExposure: Groups differing in alpha-tocopherol content; lowest 2.9 ppm, highest 28.8 ppm\nRoute: Food-matrix storage; no human administration\nDuration: 7 days at 2 C\nLimits: Food oxidation and partitioning are not human nutrient metabolism. The abstract supports a matrix-dependent association, not an intake recommendation or gamma-nonalactone-induced vitamin E depletion.\nPrimary reference: Effect of α-tocopherol on lactone formation in marbled beef and changes in lactone volatility during storage. (2012). https://pubmed.ncbi.nlm.nih.gov/22583190/ DOI: 10.1111/j.1750-3841.2012.02694.x\nAccess: Primary PubMed abstract; unresolved method details explicitly retained.","model_system":"Rendered fat from marbled beef; bovine food matrix","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73777c54-95a4-5b07-9d14-d4dd31949fb1","stable_key":"import-8600a864-6653-52c7-9718-1362c5af4577","title":"Gamma-nonalactone: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eight primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"a6fede6fbb2b70669be6846626f9c197edfd605c627d50fffa984e2b0b7ed71d","revision_id":"bb5ac9d2-d97d-59ac-a99c-ddf46d535574","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}