{"id":"aae1a6a7-6b06-5195-bcc6-8971c4e80b2f","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-nmn-phytosphingosine","predicate":"increases_in_recorded_comparison","statement":"The combined-treatment group had higher fecal phytosphingosine; its abundance correlated with selected microbial taxa.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"11dffd5b-6a7e-5e69-8849-d5b4387d635d","mechanism_event_label":"The combined-treatment group had higher fecal phytosphingosine; its abundance correlated with selected microbial taxa.","subject":{"id":"6d70addf-e302-5605-9c6a-02358209c876","slug":"nmn-apigenin-combination-2026","display_name":"NMN plus apigenin preparation in the 2026 musculoskeletal study","entity_type_key":"chemical_species"},"object":{"id":"a02862d6-8256-5368-9c54-a38fe5576ec9","slug":"phytosphingosine","display_name":"Phytosphingosine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"11dffd5b-6a7e-5e69-8849-d5b4387d635d","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-nmn-phytosphingosine-event","event_type":"experimental_observation","label":"The combined-treatment group had higher fecal phytosphingosine; its abundance correlated with selected microbial taxa.","description":"### api-nmn-phytosphingosine\n\nThe combined-treatment group had higher fecal phytosphingosine; its abundance correlated with selected microbial taxa.\nTaxon correlations do not prove that those organisms synthesized phytosphingosine. FMT and separate phytosphingosine supplementation supported follow-up routes but did not isolate an apigenin-only mechanism.\nModel and exposure: Aged mice, fecal metabolomics and microbiome correlations.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | 2026 | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468 | Access: Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6d70addf-e302-5605-9c6a-02358209c876","slug":"nmn-apigenin-combination-2026","display_name":"NMN plus apigenin preparation in the 2026 musculoskeletal study","entity_type_key":"chemical_species"},"role":"tested factor","stoichiometry":null,"state_label":"NMN plus apigenin","sequence_order":0,"notes":""},{"entity":{"id":"a02862d6-8256-5368-9c54-a38fe5576ec9","slug":"phytosphingosine","display_name":"Phytosphingosine","entity_type_key":"small_molecule"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_condition","value_text":"co-administered","comparator":"Aged controls","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"experimental_condition","value_text":"co-administered","comparator":"Aged controls","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"nmn","display_name":"NMN","entity_type_key":"small_molecule"}},{"dimension":"experimental_condition","value_text":"NMN plus apigenin","comparator":"Aged controls","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"nmn-apigenin-combination-2026","display_name":"NMN plus apigenin preparation in the 2026 musculoskeletal study","entity_type_key":"chemical_species"}},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"NMN plus apigenin\", \"comparator\": \"Aged controls\", \"endpoint\": \"The combined-treatment group had higher fecal phytosphingosine; its abundance correlated with selected microbial taxa.\", \"effect_direction\": \"increase\", \"combination\": \"joint\", \"conditions\": [{\"entity_slug\": \"nmn-apigenin-combination-2026\", \"state\": \"NMN plus apigenin\"}, {\"entity_slug\": \"nmn\", \"state\": \"co-administered\"}, {\"entity_slug\": \"apigenin\", \"state\": \"co-administered\"}]}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"Aged mice, fecal metabolomics and microbiome correlations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The combined-treatment group had higher fecal phytosphingosine; its abundance correlated with selected microbial taxa.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-nmn-phytosphingosine; Taxon correlations do not prove that those organisms synthesized phytosphingosine. FMT and separate phytosphingosine supplementation supported follow-up routes but did not isolate an apigenin-only mechanism.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"906e36fc-e9d3-5da6-8678-69e8e5249311","evidence_kind":"source_excerpt","locator":"Lines 572-578","start_line":572,"end_line":578,"excerpt":"### api-nmn-phytosphingosine\n\nThe combined-treatment group had higher fecal phytosphingosine; its abundance correlated with selected microbial taxa.\nTaxon correlations do not prove that those organisms synthesized phytosphingosine. FMT and separate phytosphingosine supplementation supported follow-up routes but did not isolate an apigenin-only mechanism.\nModel and exposure: Aged mice, fecal metabolomics and microbiome correlations.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | 2026 | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468 | Access: Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.","model_system":"Aged mice, fecal metabolomics and microbiome correlations.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}