{"id":"aadd969f-eff3-5ea6-b726-41af662e2dd1","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-mixture-glycation","predicate":"reduces_tested","statement":"The pigment-rich fermentation product at 0.2 mg/mL reduced fluorescent AGE formation by 87.1% in the BSA–fructose assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"02aefca0-7983-5eb2-b137-bc1f48efce22","mechanism_event_label":"A particular mixture changed a glycation readout.","subject":{"id":"015712d4-15a8-588c-8baa-6446b51dffab","slug":"monascus-pigment-rich-product-2024","display_name":"Pigment-rich Monascus fermentation product studied in 2024","entity_type_key":"chemical_species"},"object":{"id":"28965994-76c0-5134-b8fb-1920cc6ac540","slug":"bovine-albumin-fructose-glycation","display_name":"Bovine serum albumin–fructose glycation assay","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"02aefca0-7983-5eb2-b137-bc1f48efce22","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-mixture-glycation-event","event_type":"observed_relationship","label":"A particular mixture changed a glycation readout.","description":"The pigment-rich fermentation product at 0.2 mg/mL reduced fluorescent AGE formation by 87.1% in the BSA–fructose assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"015712d4-15a8-588c-8baa-6446b51dffab","slug":"monascus-pigment-rich-product-2024","display_name":"Pigment-rich Monascus fermentation product studied in 2024","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"28965994-76c0-5134-b8fb-1920cc6ac540","slug":"bovine-albumin-fructose-glycation","display_name":"Bovine serum albumin–fructose glycation assay","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f30a9f70-f7e3-523a-8948-5aff9593eacd","slug":"monascin","display_name":"Monascin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"92939faa-84d1-52e8-a70f-deefd2486d52","slug":"ankaflavin","display_name":"Ankaflavin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"3c379840-5688-5b5d-84c0-5950b4fd8f17","slug":"fructose","display_name":"Fructose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text PMC11120408","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free bovine albumin and fructose experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not purified ankaflavin alone, and fluorescence inhibition is not a clinical diabetes endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A particular mixture changed a glycation readout.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[38790873] Revealing the Hypoglycemic Effect of Red Yeast Rice: Perspectives from the Inhibition of α-Glucosidase and the Anti-Glycation Capability by Ankaflavin and Monascin. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38790873/ · DOI 10.3390/foods13101573","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2e09bd81-4952-524f-9bfa-590c96720ac6","evidence_kind":"source_excerpt","locator":"Lines 308-314","start_line":308,"end_line":314,"excerpt":"## red-yeast-rice-mixture-glycation\nA particular mixture changed a glycation readout.\nThe pigment-rich fermentation product at 0.2 mg/mL reduced fluorescent AGE formation by 87.1% in the BSA–fructose assay.\nModel: Cell-free bovine albumin and fructose experiment.\nLimitations: Not purified ankaflavin alone, and fluorescence inhibition is not a clinical diabetes endpoint.\nEvidence access: Primary full text PMC11120408\n[38790873] Revealing the Hypoglycemic Effect of Red Yeast Rice: Perspectives from the Inhibition of α-Glucosidase and the Anti-Glycation Capability by Ankaflavin and Monascin. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38790873/ · DOI 10.3390/foods13101573","model_system":"Cell-free bovine albumin and fructose experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}