{"id":"aad2dd25-06a9-5fde-84f9-6795e7ba031a","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-mouse-nrf2-gsh","predicate":"reduces","statement":"Luteolin reduced liver glutathione and antioxidant-enzyme expression in wild-type mice under basal and BHA-induced conditions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2060d86d-b233-5a87-b123-c1c7e9472cfb","mechanism_event_label":"An antioxidant-associated compound can lower this defense system in a particular model.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"2060d86d-b233-5a87-b123-c1c7e9472cfb","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-mouse-nrf2-gsh-event","event_type":"observed_relationship","label":"An antioxidant-associated compound can lower this defense system in a particular model.","description":"Luteolin reduced liver glutathione and antioxidant-enzyme expression in wild-type mice under basal and BHA-induced conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse liver dosing study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence of universal human glutathione depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An antioxidant-associated compound can lower this defense system in a particular model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24747074/ · DOI 10.1016/j.bbrc.2014.04.039","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3570635e-1448-59e5-a7d0-e502be0f3287","evidence_kind":"source_excerpt","locator":"Lines 452-458","start_line":452,"end_line":458,"excerpt":"## luteolin-mouse-nrf2-gsh\nAn antioxidant-associated compound can lower this defense system in a particular model.\nLuteolin reduced liver glutathione and antioxidant-enzyme expression in wild-type mice under basal and BHA-induced conditions.\nModel: Mouse liver dosing study.\nLimitations: Not evidence of universal human glutathione depletion.\nEvidence access: Primary abstract\nLuteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24747074/ · DOI 10.1016/j.bbrc.2014.04.039","model_system":"Mouse liver dosing study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}